Document Detail


Serum creatinine in very low birth weight infants during their first days of life.
MedLine Citation:
PMID:  17036033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Little is known about the relationship between gestational age (GA) or birth weight (BW) and serum creatinine (SCr) in very low birth weight (VLBW) infants. We sought to study postnatal SCr changes and determine if there is a correlation between GA or BW and SCr in VLBW infants, during their first days of life. STUDY DESIGN: Medical records of all VLBW infants, who were admitted to our neonatal intensive care unit (NICU) between 1 May 1998 and 1 May 2001, were reviewed. Medical records were reviewed for: BW, GA, gender, race, APGAR scores, mechanical ventilation, use of medications, fluid intake, urinary output, protein intake, blood urea nitrogen (BUN) and SCr during the first days of life. Patients with anuria/oliguria, major congenital anomalies, low APGAR scores at 5 min, on high ventilator settings (on the oscillator), hemodynamically unstable (on pressors, inotropes) and on indomethacin and diuretics were excluded. RESULTS: In total, 138 infants met our inclusion criteria. SCr was found to decrease postnatally, reaching a plateau on day 5 of life in all VLBW infants (repeated measure analysis of variance; P=0.004); however, there was a delay in the decrease of SCr in the subgroup of infants <29 weeks GA, and <1000 g BW. SCr (on day 5 of life) was also found to decrease with increasing GA and BW (Pearson correlation coefficient: -0.206 (P=0.05) and -0.236 (P=0.05) respectively). CONCLUSION: In VLBW infants SCr decreases significantly during the first days of life; however, in infants younger than 29 weeks GA or smaller than 1000 g BW there is a delay in the decrease of their SCr that extends beyond the first days of life. We also conclude that during the first days of life, and in VLBW infants SCr decreases with advancing GA and BW.
Authors:
A Auron; M J Mhanna
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Publication Detail:
Type:  Journal Article     Date:  2006-10-12
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  26     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-23     Completed Date:  2007-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-60     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / adverse effects
Creatinine / blood*
Female
Gentamicins / adverse effects
Gestational Age
Humans
Infant, Newborn
Infant, Premature / blood
Infant, Very Low Birth Weight / blood*
Logistic Models
Male
Respiration, Artificial
Retrospective Studies
Xanthines / adverse effects
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 0/Xanthines; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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