Document Detail

Serum creatine kinase in the diagnosis of acute myocardial infarction. Optimal sampling frequency.
MedLine Citation:
PMID:  6401336     Owner:  NLM     Status:  MEDLINE    
To document optimal sampling frequency, we reviewed creatine kinase (CK) myocardial specific isoenzyme (CKMB) results in 314 patients with suspected acute myocardial infarction (MI). In 127 patients with elevated CK/CKMB, peak CK observed using all samples (every four-hour [Q4hr] method) was compared with results that would have been obtained had samples been taken on admission and either twice daily (every 12-hour [Q12hr] method) or once daily (every 24-hour [Q24hr] method). Although average peak CK was statistically different (Q4hr greater than Q12hr greater than Q24hr), major underestimation of peak CK (greater than or equal to 500 units/L) was uncommon (3%) using the Q12hr method, suggesting that Q12hr sampling is a practical, cost-effective approach for patients with suspected acute MI.
M L Fisher; N H Carliner; L C Becker; R W Peters; G D Plotnick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  249     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  393-4     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Enzyme Tests*
Cost-Benefit Analysis
Creatine Kinase / blood*
Myocardial Infarction / diagnosis*
Time Factors
Reg. No./Substance:
0/Isoenzymes; EC Kinase

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