Document Detail

Serum creatine-kinase-BB and brain damage in high-risk newborn infants. Preliminary study with a new method for CK-BB estimation.
MedLine Citation:
PMID:  3718634     Owner:  NLM     Status:  MEDLINE    
CK-BB activity increases after hypoxic conditions associated with central nervous system disease. Fifty-four high-risk newborn babies were studied with serial measurements of CK-BB activities during the first 3 postnatal days. These values were correlated to their early neurologic outcome at 5 months of age. Data were carried out using a new and very sensitive method for estimating CK-BB activity and showed a good correlation between enzymatic values and the presence of persistent neurologic abnormalities (P less than .05). We conclude that early CK-BB determinations can be used as indicator of neonatal brain damage.
M Amato; R Gambon; G Von Muralt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  3     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-08-04     Completed Date:  1986-08-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  IM    
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MeSH Terms
Brain Damage, Chronic / diagnosis*,  etiology
Clinical Enzyme Tests*
Creatine Kinase / blood*
Hypoxia, Brain / complications,  diagnosis*
Infant, Newborn
Prospective Studies
Reg. No./Substance:
0/Isoenzymes; EC Kinase

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