Document Detail

Serum cortisol levels predict infarct size and patient mortality.
MedLine Citation:
PMID:  1452369     Owner:  NLM     Status:  MEDLINE    
We have investigated prospectively the serum cortisol response to acute myocardial infarction in 70 consecutive patients admitted to a coronary care unit and we have shown that the levels are significantly raised early in the course of the illness and prior to elevation of the cardiac specific enzyme fraction, creatine kinase MB. The magnitude of the cortisol response is related to the size of the ensuing infarction (rs = 0.54) as calculated from the total creatine kinase MB release (P < 0.001) and very high levels (> 2000 mumol/l) are predictive of mortality (P < 0.05). Serum cortisol levels may have a role in the early identification of myocardial infarction and in predicting those patients with a poor prognosis.
R J Bain; J P Fox; J Jagger; M K Davies; W A Littler; R G Murray
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of cardiology     Volume:  37     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Cardiovascular Medicine, East Birmingham Hospital, UK.
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MeSH Terms
Anistreplase / therapeutic use
Cardiac Output / drug effects,  physiology
Coronary Care Units
Creatine Kinase / blood
Heart Failure / drug therapy,  enzymology,  mortality*
Hydrocortisone / blood*
Middle Aged
Myocardial Infarction / drug therapy,  enzymology,  mortality*
Prospective Studies
Survival Rate
Reg. No./Substance:
0/Isoenzymes; 50-23-7/Hydrocortisone; 81669-57-0/Anistreplase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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