Document Detail

Serum copper concentrations in sick and well preterm infants.
MedLine Citation:
PMID:  6776255     Owner:  NLM     Status:  MEDLINE    
In order to define the range of serum copper concentrations in preterm infants and to determine the effect of growth upon these values, serial serum copper concentrations were measured in 26 preterm infants over their first six weeks of life. Fourteen healthy, growing preterm infants (Group I) had mean serum copper concentrations below 32 microgram/dl throughout the study. Clinical and hematologic signs of copper deficiency which responded promptly to the oral administration of copper sulfate were noted in five of these 14 infants. Twelve ill preterm infants (Group II-A), who received parenteral nutrition without supplemental copper and had slow rates of growth, had mean serum copper concentrations above 50 micrograms/dl after the first week of life. Seven surviving from Group II-A (Group II-B) had a decrease in mean serum copper concentrations to values similar to those in Group I after two weeks of oral feedings and resumption of normal growth. Our findings suggest that preterm infants who have normal growth while receiving oral feedings are at significant risk for developing copper deficiency.
J I Manser; C S Crawford; E E Tyrala; N L Brodsky; W D Grover
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  97     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Transfusion
Bottle Feeding / adverse effects
Ceruloplasmin / analysis
Copper / blood*,  deficiency
Infant Food
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / blood*
Parenteral Nutrition
Reg. No./Substance:
7440-50-8/Copper; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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