Document Detail

Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass.
MedLine Citation:
PMID:  3755198     Owner:  NLM     Status:  MEDLINE    
Twenty-six consecutive pediatric patients undergoing reparative procedures necessitating cardiopulmonary bypass were prospectively studied to determine changes in serum levels of 6-keto-prostaglandin F1 alpha and thromboxane B2. Cardiac lesions included acyanotic lesions (five patients), obstructive lesions (10 patients), and right-to-left shunts (11 patients). There was a significant (p less than 0.05) increase in 6-keto-prostaglandin F1 alpha from preoperative levels measured at the time of arterial and venous cannula insertion. This concentration was maintained throughout cardiopulmonary bypass and remained significantly elevated (p less than 0.001) in the recovery room, but returned to preoperative levels by the morning after the operation. Preoperative levels of thromboxane B2 varied widely and were not significantly different from intraoperative levels. The postoperative levels of thromboxane B2, however, were significantly different (p less than 0.05) from the intraoperative levels. In the pediatric age group undergoing cardiopulmonary bypass, 6-keto-prostaglandin F1 alpha and thromboxane B2 change during bypass but do not significantly differ when preoperative levels are compared to postoperative values.
W H Fleming; L B Sarafian; M P Leuschen; M C Newland; E M Kennedy; J D Kugler; J W Chapin; B J Hurlbert; D L Bolam; R M Nelson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  92     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-07-29     Completed Date:  1986-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  AIM; IM    
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood*
Cardiopulmonary Bypass*
Child, Preschool
Evaluation Studies as Topic
Infant, Newborn
Intraoperative Period
Postoperative Period
Thromboxane B2 / blood*
Reg. No./Substance:
54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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