| Serum concentrations of bupivacaine during prolonged continuous paravertebral infusion in young infants. | |
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MedLine Citation:
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PMID: 9301381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied the efficacy of prolonged, continuous paravertebral infusion of bupivacaine for the management of post-thoracotomy pain in 22 infants with a median age of 1.5 weeks (range 1 day to 20.4 weeks). Immediately before chest closure, 0.25% bupivacaine 1.25 mg kg-1 was given into an extrapleural paravertebral catheter, inserted under direct vision. Subsequently, 0.125% bupivacaine with adrenaline 1:400000 was infused at a rate of 0.2 ml kg-1 h-1 for 48 h. We confirmed that extrapleural paravertebral catheter placement under direct vision was easy in neonates and infants. The technique provided effective post-operative pain relief in 86% of patients, with three patients requiring morphine in addition. Mean serum concentration of bupivacaine after 48 h was 1.60 (0.67) micrograms ml-1, but bupivacaine concentrations > 3 micrograms ml-1 were found in three patients at 30-48 h. There were no major complications relating to the technique, and paravertebral block was an effective method of providing prolonged post-thoracotomy analgesia in these young infants. |
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Authors:
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S L Cheung; P D Booker; R Franks; M Pozzi |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 79 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-03 Completed Date: 1997-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 9-13 Citation Subset: IM |
Affiliation:
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Royal Liverpool Children's NHS Trust. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia
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methods Anesthetics, Local / administration & dosage*, blood, therapeutic use Bupivacaine / administration & dosage*, blood, therapeutic use Drug Administration Schedule Drug Therapy, Combination Epinephrine / therapeutic use Humans Infant Infant, Newborn Infusions, Parenteral Pain, Postoperative / prevention & control* Thoracotomy* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 2180-92-9/Bupivacaine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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