Document Detail

Serum concentrations of bupivacaine during prolonged continuous paravertebral infusion in young infants.
MedLine Citation:
PMID:  9301381     Owner:  NLM     Status:  MEDLINE    
We have studied the efficacy of prolonged, continuous paravertebral infusion of bupivacaine for the management of post-thoracotomy pain in 22 infants with a median age of 1.5 weeks (range 1 day to 20.4 weeks). Immediately before chest closure, 0.25% bupivacaine 1.25 mg kg-1 was given into an extrapleural paravertebral catheter, inserted under direct vision. Subsequently, 0.125% bupivacaine with adrenaline 1:400000 was infused at a rate of 0.2 ml kg-1 h-1 for 48 h. We confirmed that extrapleural paravertebral catheter placement under direct vision was easy in neonates and infants. The technique provided effective post-operative pain relief in 86% of patients, with three patients requiring morphine in addition. Mean serum concentration of bupivacaine after 48 h was 1.60 (0.67) micrograms ml-1, but bupivacaine concentrations > 3 micrograms ml-1 were found in three patients at 30-48 h. There were no major complications relating to the technique, and paravertebral block was an effective method of providing prolonged post-thoracotomy analgesia in these young infants.
S L Cheung; P D Booker; R Franks; M Pozzi
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  79     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-03     Completed Date:  1997-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Royal Liverpool Children's NHS Trust.
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MeSH Terms
Analgesia / methods
Anesthetics, Local / administration & dosage*,  blood,  therapeutic use
Bupivacaine / administration & dosage*,  blood,  therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Epinephrine / therapeutic use
Infant, Newborn
Infusions, Parenteral
Pain, Postoperative / prevention & control*
Reg. No./Substance:
0/Anesthetics, Local; 2180-92-9/Bupivacaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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