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Serum concentrations of NSE and S100B in spinocerebellar ataxia type 3/Machado-Joseph disease.
MedLine Citation:
PMID:  21743141     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective To determine the neuronal damage or loss and gliosis at the cellular level in spinocerebellar ataxia type 3/Machado-Joseph disease(SCA3/MJD), and evaluate the potential use of neuron-specific enolase (NSE) and protein S 100 B(S100B) serum concentrations as biochemical markers. Methods Serum concentrations of NSE and S100B were measured in 102 SCA3/MJD patients and 100 healthy subjects matched by sex and age. The correlations between both markers and age, age of onset, disease duration, CAG repeat size, scores of international cooperative ataxia rating scale(ICARS), and scale for the assessment and rating of ataxia(SARA) were analyzed. Results Compared with the healthy controls, patients with SCA3/MJD had higher NSE serum concentrations [(6.95±2.83)ng/mL vs (4.83±1.70) ng/mL, P<0.05] and higher S100B serum concentrations [(0.07±0.06) ng/mL vs (0.05±0.02) ng/mL, P<0.05]. In the SCA3/MJD patients group, NSE levels presented a positive correlation with age, disease duration, ICARS scores and SARA scores, whereas S100B levels did not correlate with age, age of onset, disease duration, ICARS scores and SARA scores. CAG repeat size did not correlate with the NSE levels and S100B levels in different age groups of SCA3/MJD patients. Conclusion Serum NSE might be a useful marker to monitor disease progression and represent the degree of severity of a certain disease. Elevated S100B serum concentrations in patients compared to healthy controls may suggest an application of this protein as a peripheral marker of brain impairment in SCA3/MJD.
Authors:
Jie Zhou; Lifang Lei; Yuting Shi; Junling Wang; Hong Jiang; Lu Shen; Beisha Tang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences     Volume:  36     ISSN:  1672-7347     ISO Abbreviation:  Zhong Nan Da Xue Xue Bao Yi Xue Ban     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230586     Medline TA:  Zhong Nan Da Xue Xue Bao Yi Xue Ban     Country:  China    
Other Details:
Languages:  eng     Pagination:  504-10     Citation Subset:  IM    
Affiliation:
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
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