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Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism.
MedLine Citation:
PMID:  21251056     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim  Anti-Müllerian hormone (AMH) is produced by fetal Sertoli cells at the time of sexual differentiation and is responsible for the regression of the Müllerian ducts in the male fetus. AMH is a testis specific marker of diagnostic value in infants with ambiguous genitalia or with bilateral cryptorchidism. However, little is known about AMH in boys and adult men with normal or abnormal gonadal function. We therefore aimed at determining circulating AMH concentrations in patients with 47,XXY Klinefelter syndrome with or without cryptorchidism. Methods  AMH was determined in 95 47,XXY patients aged 0.2 to 64.5 years, of which 12 patients had a history of cryptorchidism. Results  AMH was within the normal range in Klinefelter boys until puberty. The pubertal decline was delayed, especially in patients with a history of cryptorchidism. AMH was below -2SD in 85% of adult KS. Conclusion  AMH secretion in patients with 47,XXY Klinefelter syndrome was within normal limits during mini-puberty and until puberty. Thereafter, AMH declined to subnormal levels in all patients. We hypothesize that this decline was a result of the hyalinisation of seminiferous tubules in relation to puberty, rather than caused by disrupted regulatory mechanisms at the level of the pituitary-gonadal axis.
Authors:
Lise Aksglaede; Peter Christiansen; Kaspar Sørensen; Malene Boas; Allan Linneberg; Katharina M Main; Anna-Maria Andersson; Niels Erik Skakkebaek; Anders Juul
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-19
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Foundation Acta Paediatrica.
Affiliation:
University Department of Growth and Reproduction Rigshospitalet Copenhagen, Denmark Research Centre for Prevention and Health Glostrup University Hospital Glostrup, Denmark.
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