Document Detail

Serum concentrations of 25-hydroxyvitamin D in rickets of extremely premature infants.
MedLine Citation:
PMID:  423037     Owner:  NLM     Status:  MEDLINE    
Nine premature infants developed radiographic and biochemical rickets at a mean +/- SD of 12.6 +/- 2.8 weeks of age. Serum 25-hydroxyvitamin D concentrations were all low, with a mean of less than 3.6 +/- 2.1 ng/ml. The mean average daily intake of vitamin D since birth had been 300 +/- 181 IU, and the mean average daily intake during the week of diagnosis was 587 +/- 313 IU. All of the infants were extremely premature (mean weight 948 +/- 153 gm, mean gestation 27.7 +/- 1.1 weeks), and were being fed either a low-calcium "human milk-like" formula or a soy formula. It is postulated that low-calcium intake may have increased 25-OHD utilization in the face of a decreased ability of the extremely premature infant to produce 25-OHD. Because of multiple factors leading to both decreased production and possible increased utilization of 25-OHD, such infants have an increased requirement for vitamin D to maintain normal serum 25-OHD concentrations, and daily intakes of at least 400 IU vitamin D orally must be assured. Serum 25-OHD measurements and radiographs may be important in following infants at risk.
N Hoff; J Haddad; S Teitelbaum; W McAlister; L S Hillman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  94     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-05-26     Completed Date:  1979-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  460-6     Citation Subset:  AIM; IM    
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MeSH Terms
Hydroxycholecalciferols / blood*,  metabolism
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature, Diseases / blood*,  pathology,  therapy
Nutritional Requirements
Ribs / pathology
Rickets / blood*,  drug therapy,  pathology,  radiography
Vitamin D / therapeutic use
Reg. No./Substance:
0/Hydroxycholecalciferols; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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