Document Detail

Serum concentrations of 10 acute-phase proteins in healthy term and preterm infants from birth to age 6 months.
MedLine Citation:
PMID:  7536645     Owner:  NLM     Status:  MEDLINE    
Aiming to define the evolution pattern of 10 acute-phase proteins in early infancy, we measured nephelometrically the serum concentrations of albumin, prealbumin, retinol-binding protein, transferrin, ceruloplasmin, hemopexin, haptoglobin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, and alpha 1-antitrypsin in 395 term and preterm infants (gestational ages 26-41 weeks). Measurements were performed within 24 h after birth and then at the end of 1 (n = 171), 3 (n = 155), and 6 (n = 90) months afterwards. Data obtained from 250 healthy adults were used as adult reference values. All proteins increased progressively with postnatal age, except for alpha 1-antitrypsin, which remained stable from birth to the 6th month. Concentrations of almost all measured proteins were significantly lower in preterm than in term infants in the first 3 months. Compared with adult values, alpha 2-macroglobulin and alpha 1-antitrypsin were higher in infants throughout the 6 months. The other proteins were significantly lower at birth than adult values but after 6 months, only albumin, prealbumin, retinol-binding protein, and alpha 1-acid glycoprotein still remained lower in infants. Thus both gestational and postnatal age should be considered when interpreting concentrations of these proteins in early infancy.
F Kanakoudi; V Drossou; V Tzimouli; E Diamanti; T Konstantinidis; A Germenis; G Kremenopoulos
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  41     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-22     Completed Date:  1995-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  IM    
First Department of Pediatrics, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Acute-Phase Proteins / analysis*
Aging / blood
Ceruloplasmin / analysis
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Orosomucoid / analysis
Reference Values
Retinol-Binding Proteins / analysis
Serum Albumin / analysis
Transferrin / analysis
alpha 1-Antitrypsin / analysis
alpha-Macroglobulins / analysis
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Orosomucoid; 0/Retinol-Binding Proteins; 0/Serum Albumin; 0/alpha 1-Antitrypsin; 0/alpha-Macroglobulins; 11096-37-0/Transferrin; EC
Comment In:
Clin Chem. 1995 Nov;41(11):1673   [PMID:  7586567 ]

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