| Serum concentration and serum half-life of digoxin in premature and mature newborns. | |
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MedLine Citation:
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PMID: 865943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum concentrations and half-life times of digoxin were determined in ten mature and nine premature newborns. Median serum digoxin concentration was 2.3 ng/ml (1.2 to 3.5 ng/ml) in mature newborns and 2.4 ng/ml (1.5 to 4.5 ng/ml) in premature newborns. Median serum digoxin half-life was 35 hours (17 to 52 hours) in mature newborns and 57 hours (38 to 88 hours) in premature newborns. The difference in serum digoxin half-life between the two groups is statistically significant. The relatively long serum digoxin half-life in premature newborns is probably due to immature renal function in this group. The data emphasize the need for cautious digoxin administration, especially in premature infants. |
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Authors:
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D Lang; G von Bernuth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 59 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-07-18 Completed Date: 1977-07-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 902-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Digoxin
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administration & dosage,
blood*,
therapeutic use Half-Life Humans Infant, Newborn Infant, Newborn, Diseases / blood*, drug therapy Infant, Premature, Diseases / blood*, drug therapy |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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