Document Detail


Serum concentration and serum half-life of digoxin in premature and mature newborns.
MedLine Citation:
PMID:  865943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum concentrations and half-life times of digoxin were determined in ten mature and nine premature newborns. Median serum digoxin concentration was 2.3 ng/ml (1.2 to 3.5 ng/ml) in mature newborns and 2.4 ng/ml (1.5 to 4.5 ng/ml) in premature newborns. Median serum digoxin half-life was 35 hours (17 to 52 hours) in mature newborns and 57 hours (38 to 88 hours) in premature newborns. The difference in serum digoxin half-life between the two groups is statistically significant. The relatively long serum digoxin half-life in premature newborns is probably due to immature renal function in this group. The data emphasize the need for cautious digoxin administration, especially in premature infants.
Authors:
D Lang; G von Bernuth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  59     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-18     Completed Date:  1977-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  902-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Digoxin / administration & dosage,  blood*,  therapeutic use
Half-Life
Humans
Infant, Newborn
Infant, Newborn, Diseases / blood*,  drug therapy
Infant, Premature, Diseases / blood*,  drug therapy
Chemical
Reg. No./Substance:
20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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