Document Detail


Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding.
MedLine Citation:
PMID:  8310985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of rapeseed oil with and without added squalene was studied on serum lipids and cholesterol metabolism. Dietary rapeseed oil reduced LDL cholesterol by 10%, increased cholesterol precursors and plant sterols, and decreased cholestanol in serum during a 6-wk baseline period from initial values. Addition of 1 g squalene in rapeseed oil for 9 wk caused net increases in serum total, VLDL-, IDL-, and LDL-cholesterol concentrations by 12%, 34%, 28%, and 12%, respectively; squalene by five times; and cholesterol precursor sterols by up to 60%. Fecal squalene was 15% of the dietary intake, cholesterol absorption was unchanged, fecal neutral sterols were significantly increased, whereas, in contrast to the precursor sterols, the increase in cholesterol synthesis was insignificant. LDL apolipoprotein B was increased by 14% with unchanged removal but enhanced transport of LDL apolipoprotein B. A negative correlation between the changes in LDL apolipoprotein B removal and LDL cholesterol suggests that LDL receptor activity was down-regulated, allowing more of the LDL precursor lipoproteins to be converted to LDL. A subsequent 6-wk period on 0.5 g squalene/d normalized serum sterols.
Authors:
T A Miettinen; H Vanhanen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  59     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-16     Completed Date:  1994-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  356-63     Citation Subset:  AIM; IM    
Affiliation:
Second Department of Medicine, University of Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Apolipoproteins A / analysis
Apolipoproteins B / analysis
Body Weight
Brassica
Cholesterol / blood*,  metabolism
Dietary Fats / administration & dosage,  pharmacology
Dose-Response Relationship, Drug
Drug Antagonism
Humans
Hypercholesterolemia / blood,  diet therapy*
Longitudinal Studies
Male
Middle Aged
Phospholipids / blood
Plant Oils / administration & dosage,  pharmacology*
Squalene / administration & dosage,  pharmacokinetics,  pharmacology*
Sterols / blood
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Apolipoproteins B; 0/Dietary Fats; 0/Phospholipids; 0/Plant Oils; 0/Sterols; 0/Triglycerides; 111-02-4/Squalene; 57-88-5/Cholesterol; 8002-13-9/rapeseed oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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