| Serum complement pattern in essential mixed cryoglobulinaemia. | |
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MedLine Citation:
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PMID: 668194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In twenty-six patients affected by essential cryoglobulinaemia, 188 determinations of serum complement components (SCC) were made. A peculiar pattern was observed which was characterized by: (a) low levels of early components (Clq, Cls and C4), (b) normal levels of C3 and high concentrations of late components (C5, C9) and (c) CH50 values significantly lower than normal. No relationship could be observed between early SCC and C3 levels. Thirty-three crossed immunoelectrophoreses were performed in thirteen patient's blood samples. The C3c peaks were not different from normal. Follow-up data (156 serum samples from twenty-four patients) during a 6-40 month period showed a non-homogeneous SCC behaviour. However, no relationship was found between the complement concentrations and clinical score. These findings suggest that SCC abnormalities are related to a complement hyposynthesis, which could be caused by a reduced C2 production or by a negative feedback effect of active components or their fragments. |
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Authors:
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A Tarantino; A Anelli; A Costantino; A De Vecchi; G Monti; L Massaro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 32 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1978 Apr |
Date Detail:
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Created Date: 1978-09-30 Completed Date: 1978-09-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 77-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Complement C3
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metabolism Complement System Proteins / metabolism* Cryoglobulins* Female Humans Immunoelectrophoresis, Two-Dimensional Male Paraproteinemias / immunology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Cryoglobulins; 9007-36-7/Complement System Proteins |
| Comments/Corrections | |
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