Document Detail

Serum complement pattern in essential mixed cryoglobulinaemia.
MedLine Citation:
PMID:  668194     Owner:  NLM     Status:  MEDLINE    
In twenty-six patients affected by essential cryoglobulinaemia, 188 determinations of serum complement components (SCC) were made. A peculiar pattern was observed which was characterized by: (a) low levels of early components (Clq, Cls and C4), (b) normal levels of C3 and high concentrations of late components (C5, C9) and (c) CH50 values significantly lower than normal. No relationship could be observed between early SCC and C3 levels. Thirty-three crossed immunoelectrophoreses were performed in thirteen patient's blood samples. The C3c peaks were not different from normal. Follow-up data (156 serum samples from twenty-four patients) during a 6-40 month period showed a non-homogeneous SCC behaviour. However, no relationship was found between the complement concentrations and clinical score. These findings suggest that SCC abnormalities are related to a complement hyposynthesis, which could be caused by a reduced C2 production or by a negative feedback effect of active components or their fragments.
A Tarantino; A Anelli; A Costantino; A De Vecchi; G Monti; L Massaro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  32     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-09-30     Completed Date:  1978-09-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-85     Citation Subset:  IM    
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MeSH Terms
Complement C3 / metabolism
Complement System Proteins / metabolism*
Immunoelectrophoresis, Two-Dimensional
Paraproteinemias / immunology*
Time Factors
Reg. No./Substance:
0/Complement C3; 0/Cryoglobulins; 9007-36-7/Complement System Proteins

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