Document Detail


Serum choline esterase and liver function among a group of organophosphorus pesticides sprayers in Egypt.
MedLine Citation:
PMID:  2135058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was initiated to investigate the long term effect of exposure to organophosphorus pesticides (O.P), with consideration to bilharziasis (an endemic parasitic disease in Egypt, usually associated with liver fibrosis). Serum levels of choline esterase (Ch E), glutamic pyruvic transaminase (SGPT), alkaline phosphatase (Alk. Ph.) and proteins were estimated among 100 (O.P.) sprayers with various duration of exposure (3 to 15 years) and among 60 controls. O.P. sprayers showed significantly higher, SGPT and Alk. Ph. and lower Ch E and serum proteins than the controls. Among sprayers, duration of exposure to O.P. was significantly correlated with their levels of Ch E, SGPT, and Alk. Ph. but not with serum proteins. Compared to other parameters, SGPT seems to be a good indicator of the hepatic effect of long term exposure to O.P. Bilharzial infection did not modify the effect of O.P. pesticides on the above mentioned parameters. Ch E of smoker sprayers was significantly less than that of non smokers. This was attributed to increased absorbtion of O.P. during smoking at work places.
Authors:
A A Kamal; M T Elgarhy; F Maklady; M A Mostafa; A Massoud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal de toxicologie clinique et expérimentale     Volume:  10     ISSN:  0753-2830     ISO Abbreviation:  J Toxicol Clin Exp     Publication Date:    1990 Nov-Dec
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8606713     Medline TA:  J Toxicol Clin Exp     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  427-35     Citation Subset:  IM    
Affiliation:
Department of Community, Faculty of Medicine, Ain Shams University, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Adult
Agricultural Workers' Diseases / blood,  chemically induced*
Cholinesterases / blood*
Drug-Induced Liver Injury / blood,  etiology*
Egypt / epidemiology
Humans
Insecticides / adverse effects*
Male
Organophosphorus Compounds*
Schistosomiasis / complications
Smoking
Chemical
Reg. No./Substance:
0/Insecticides; 0/Organophosphorus Compounds; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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