Document Detail

Serum cholesterol in Wisconsin epidemiologic study of diabetic retinopathy.
MedLine Citation:
PMID:  1547687     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe serum total and high-density lipoprotein (HDL) cholesterol in a sample of people with diabetes. RESEARCH DESIGN AND METHODS: Subjects were those who participated in the 1984-1986 Wisconsin Epidemiologic Study of Diabetic Retinopathy. Data were from three groups of subjects: 304 younger-onset and 185 older-onset people taking insulin and 162 older-onset individuals not taking insulin. Serum lipids, duration of diabetes, glycosylated hemoglobin, diastolic blood pressure, sex, age, serum creatinine, units of insulin per kilogram per day, smoking status, serum C-peptide level, and alcohol use were analyzed statistically. RESULTS: In subjects taking insulin, glycosylated hemoglobin was correlated most strongly with total cholesterol. In those not taking insulin, C-peptide was correlated most strongly. In subjects taking insulin, the units used per day (fewer) and sex (female) were significantly associated with higher HDL cholesterol, and in both older-onset groups, serum C-peptide was significantly associated with lower HDL cholesterol. Mean total cholesterol levels were generally higher and mean HDL cholesterol levels were generally lower than those found in a nondiabetic comparison group. CONCLUSION: By the National Cholesterol Education Program guidelines, 17% of younger-onset and 30% of older-onset insulin users and 32% of older-onset subjects not taking insulin were in the high-risk range for total cholesterol. Lower levels of glycosylated hemoglobin might result in lower cholesterol levels.
B E Klein; S E Moss; R Klein; T S Surawicz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes care     Volume:  15     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-7     Citation Subset:  IM    
University of Wisconsin, Department of Ophthalmology, Madison 53792.
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MeSH Terms
Age Factors
Aged, 80 and over
Blood Pressure
Body Mass Index
Cholesterol / blood*
Cholesterol, HDL / blood
Creatinine / blood
Diabetes Mellitus, Type 1 / blood*,  epidemiology,  physiopathology
Diabetes Mellitus, Type 2 / blood*,  epidemiology,  physiopathology
Diabetic Retinopathy / blood*,  epidemiology,  physiopathology
Hemoglobin A, Glycosylated / analysis
Middle Aged
Sex Characteristics
Wisconsin / epidemiology
Grant Support
Reg. No./Substance:
0/Cholesterol, HDL; 0/Hemoglobin A, Glycosylated; 57-88-5/Cholesterol; 60-27-5/Creatinine

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