| Serum cholesterol falls spontaneously in nephrotic patients with progressive renal disease. | |
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MedLine Citation:
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PMID: 8516496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Total cholesterol (TC) levels were lower than expected in some patients with advanced renal disease and nephrotic-range proteinuria. Studies of 35 clinically stable nonuremic patients and of 12 nephrotic patients with advancing renal failure were therefore performed. Analysis of pooled biochemical data from 35 patients who were hypercholesterolemic on entry to the clinic revealed a positive correlation between TC and reciprocal creatinine (l/Cr) while serum albumin (ALB) was negatively correlated with l/Cr and TC. In the 12 nephrotic patients with negative reciprocal creatinine slopes there was a strong correlation between the slopes of l/Cr and TC. These data suggest that plasma cholesterol falls in the nephrotic hypercholesterolemic patients in whom renal disease progresses, and that the slopes of plasma cholesterol and reciprocal creatinine are closely related. |
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Authors:
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J F Moorhead; W Persaud; Z Varghese; P Sweny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Renal failure Volume: 15 ISSN: 0886-022X ISO Abbreviation: Ren Fail Publication Date: 1993 |
Date Detail:
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Created Date: 1993-07-19 Completed Date: 1993-07-19 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 389-93 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Royal Free Hospital, Hampstead, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholesterol
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blood* Creatinine / blood Female Humans Hypercholesterolemia / blood*, complications Kidney Failure, Chronic / blood*, complications Male Nephrotic Syndrome / blood*, complications Regression Analysis Serum Albumin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 57-88-5/Cholesterol; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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