Document Detail

Serum chitotriosidase activity, a marker of activated macrophages, predicts new cardiovascular events independently of C-reactive protein.
MedLine Citation:
PMID:  17290100     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: C-reactive protein (CRP) is a well-established inflammation marker associated with cardiovascular risk. However, its relationship with chitotriosidase activity, a novel marker of activated macrophages highly expressed in human atherosclerotic plaques, is unknown. Therefore, we sought to determine if serum chitotriosidase activity predicts the risk of new coronary events, and to analyze its relationship with CRP. METHODS: Chitotriosidase activity and genotype, and high-sensitivity CRP were measured at baseline in 133 middle-aged men with stable coronary heart disease, who were followed for the occurrence of cardiovascular morbidity and mortality for a mean of 4 years. We studied the value of these proteins in predicting the risk of new cardiovascular events. RESULTS: Serum chitotriosidase activity was higher in the group of subjects with a prespecified major event (nonfatal myocardial infarction, nonfatal ischemic stroke, coronary revascularization procedures and death from cardiovascular causes) than in the group of subjects without event, 116 +/- 30.9 nmol/ml x h versus 74.2 +/- 5.69 nmol/ml x h, respectively (p = 0.042). The baseline values of chitotriosidase activity and CRP did not correlate (R = 0.104, p = 0.266), but both parameters were related to a reduction of event-free survival in the Cox regression analysis, with relative risks of 2.61 (p = 0.060) and 2.56 (p = 0.019), respectively. Chitotriosidase activity seems to be a better marker for new events occurring after 2 years of follow-up than in the first 2 years. Both markers had similar predictive values, and their sensitivity (64%) and negative predictive value (84%) were improved when combined. CONCLUSIONS: Our results suggest that serum chitotriosidase activity predicts the risk of new cardiovascular events in the following 4 years. This new cardiovascular risk marker is independent of CRP and, when combined, the prediction of the risk of new cardiovascular events and the identification of a lower risk group seem to improve.
Marta Artieda; Ana Cenarro; Alberto Gañán; Antonela Lukic; Eva Moreno; José Puzo; Miguel Pocoví; Fernando Civeira
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-09
Journal Detail:
Title:  Cardiology     Volume:  108     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  297-306     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis
Coronary Disease / blood*
Hexosaminidases / blood*
Macrophages / physiology
Middle Aged
Predictive Value of Tests
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.-/chitotriosidase

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