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Serum chemokine levels and developmental outcome in preterm infants.
MedLine Citation:
PMID:  21493017     Owner:  NLM     Status:  Publisher    
BACKGROUND: Cytokines and chemokines during perinatal period may involve the neurological development of newborns. AIMS: We investigated the association of circulating chemokines during neonatal period with the outcome of premature infants. STUDY DESIGN: The prospective study enrolled 29 very low birth weight (<1500g) and appropriate-for-date infants having no underlying diseases. Serum concentrations of chemokines (CXCL8, CXCL9, CXCL10 and CCL2) and cytokines at birth and 4weeks postnatal age were measured. Developmental quotients (DQ) at 3years of age by the Kyoto Scale of Psychological Development were studied for the association with chemokine/cytokine levels and clinical variables including chorioamnionitis, Apgar scores, ventilator treatment and supplemental oxygen. RESULTS: CXCL8 levels at birth and days of ventilator treatment were negatively, CCL2 levels at 4weeks after birth and 5-minute Apgar scores were positively correlated with the DQ of postural-motor [P-M] area at 3years of age, respectively (CXCL8: correlation coefficient [CC]=-0.394, p=0.037, ventilation: CC=-0.518, p=0.006, CCL2: CC=0.528, p=0.013, and Apgar score: CC=0.521, p=0.005). Infants showing both ≥50pg/ml of CXCL8 at birth and <250pg/ml of CCL2 4weeks after birth had lower DQ of P-M than those who did not (p<0.001). Multivariate analyses indicated that CCL2 levels at 4weeks of age were higher in infants who attained normal DQ of P-M (≥85) (adjusted mean, 338.4 [95% confidence interval, 225.5-507.8]) than in those who did not (<85) (159.0, [108.2-233.7]) (p=0.019). CONCLUSION: Circulating patterns of CXCL8 (IL-8) and CCL2 (MCP-1) during the neonatal period might affect the neurological development of preterm infants.
Tadamune Kinjo; Shouichi Ohga; Masayuki Ochiai; Satoshi Honjo; Tamami Tanaka; Yasushi Takahata; Kenji Ihara; Toshiro Hara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-13
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Comprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, Japan.
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