| Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. | |
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MedLine Citation:
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PMID: 16433853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The major theory implicating diet with allergic diseases is associated with altered food consumption and subsequent changes in fatty acid composition. OBJECTIVE: To investigate fatty acid compositions among infants with atopic and non-atopic eczema and healthy infants and to evaluate the expediency of non-invasive cheek cell phospholipid fatty acid composition as a marker in patients with eczema. METHODS: Diagnosis of eczema in infants was confirmed clinically and by positive (atopic eczema, n=6) or negative (non-atopic eczema, n=6) skin prick testing in comparison with controls (n=19). The fatty acid compositions of infant cheek cell and serum phospholipids and breast milk total lipids were analysed by gas chromatography. RESULTS: The distinction between atopic and non-atopic eczema was manifested in cheek cell phospholipids as linoleic acid (14.69 (13.67-15.53)% of total fatty acids; the median (interquartile range)), the sum of n-6 fatty acids (19.94 (19.06-20.53)%) and the sum of polyunsaturated fatty acids (22.70 (21.31-23.28)%) were higher in infants with atopic eczema compared with non-atopic eczema (12.69 (10.87-13.93); 17.72 (15.63-18.91) and 19.90 (17.64-21.06), respectively; P<0.05) and controls (12.50 (12.16-13.42); 18.19 (17.43-18.70) and 20.32 (19.32-21.03), respectively; P<0.05). Serum phospholipid gamma-linolenic acid was lower in both atopic and non-atopic eczema compared with controls (P<0.05) and additionally eicosapentaenoic acid was higher in atopic eczema compared with controls (P<0.05). CONCLUSION: These preliminary results suggest differences in fatty acid compositions between the two types of eczema, calling for further evaluation in a larger setting. The two types of eczema may be regulated by different immunological processes, and fatty acids may have a more profound role in the atopic type. |
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Authors:
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K Laitinen; J Sallinen; K Linderborg; E Isolauri |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 36 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-25 Completed Date: 2006-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 166-73 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Turku University Central Hospital, Turku, Finland. kirsi.laitinen@utu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Cheek Chromatography, Gas Dermatitis, Atopic / metabolism* Eczema / metabolism* Fatty Acids / analysis*, blood Humans Infant Infant, Newborn Linoleic Acid / analysis Lipids / analysis Milk, Human / chemistry* Mouth Mucosa / chemistry, cytology Phospholipids / analysis Statistics, Nonparametric alpha-Linolenic Acid / analysis |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Lipids; 0/Phospholipids; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid |
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