Document Detail

Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure.
MedLine Citation:
PMID:  20091772     Owner:  NLM     Status:  MEDLINE    
High intracranial pressure (ICP) is a prominent secondary pathology after traumatic brain injury (TBI) and is a major contributor to morbidity and mortality. Currently, there are no clinically proven methods for predicting which TBI patients will develop high ICP. In the present study, we examined whether the serum levels of the copper-binding protein ceruloplasmin are differentially altered in patients with elevated ICP (> or =25 mmHg) vs. those whose ICP remained below 20 mmHg throughout the study period. Consistent with its role as an acute-phase reactant, we found that ceruloplasmin levels were significantly increased by 3 days post-TBI compared with healthy volunteers. However, prior to this delayed increase, ceruloplasmin levels during the first 24 hr following injury were found to be significantly reduced in patients who subsequently developed high ICP. This decrease was found to have prognostic accuracy in delineating TBI patients based on their ICP status (cutoff of 140 microg/ml; sensitivity: 87%, specificity: 73%), Likewise, low total serum copper (below 1.32 microg/ml) was also found to be predictive of high ICP (sensitivity 86%, specificity 73%). These results suggest that initial serum ceruloplasmin/copper levels may have diagnostic value in predicting patients at risk for developing high intracranial pressure.
Pramod K Dash; John B Redell; Georgene Hergenroeder; Jing Zhao; Guy L Clifton; Anthony Moore
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  88     ISSN:  1097-4547     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1719-26     Citation Subset:  IM    
Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Brain Injuries / blood*,  complications*
Ceruloplasmin / metabolism*
Copper / blood*
Enzyme-Linked Immunosorbent Assay / methods
Intracranial Hypertension / blood*,  complications*
Middle Aged
Time Factors
Young Adult
Reg. No./Substance:
0/Biological Markers; 7440-50-8/Copper; EC

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