Document Detail

Serum, cerebrospinal fluid, and brain levels of bile acids in patients with fulminant hepatic failure.
MedLine Citation:
PMID:  604189     Owner:  NLM     Status:  MEDLINE    
Bile acid levels were measured in the sera, cerebrospinal fluid (CSF), and brain tissue of 10 patients immediately after death from fulminant hepatic (FHF). Serum bile acids in FHF were predominantly conjugated, and total bile acid levels were higher in all 10 patients than in normal controls (85.9 +/- SE 8.4 compared with 5.7 +/- 0.4 nmol/ml, P less than 0.001). Small but significant amounts could be detected in CSF (range 1.2-5.3 nmol total bile acid/ml) and brain biopsies (1.0-18.8 nmol/g wet weight) of FHF patients, whereas none could be detected in CSF and brain biopsies of patients dying without evidence of liver disease. There was no relationship between serum, CSF, or brain levels and duration of coma, or presence of cerebral oedema found in five FHF patients at necropsy. However, serum bile acid levels were similar in FHF to those found in chronic liver disease without encephalopathy and lower than those found to inhibit brain respiration in vitro. A primary role for these compounds in the pathogenesis of coma in FHF therefore seems unlikely.
B Bron; R Waldram; D B Silk; R Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  18     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  692-6     Citation Subset:  AIM; IM    
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MeSH Terms
Bile Acids and Salts / analysis*,  blood,  cerebrospinal fluid
Brain Chemistry*
Hepatic Encephalopathy / metabolism
Liver Diseases / metabolism*
Middle Aged
Reg. No./Substance:
0/Bile Acids and Salts

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