Document Detail


Serum and cerebrospinal fluid S100B, neuron specific enolase, and total tau protein in acute encephalopathy with biphasic seizures and late reduced diffusion: A diagnostic validity.
MedLine Citation:
PMID:  21883688     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is characterized clinically by biphasic seizures and late MRI abnormalities, such as reduced subcortical diffusion from day 3 onwards, often accompanied with some neurological sequelae. In the early stages of the disease, AESD closely resembles its far more prevalent and relatively benign counterpart, febrile seizure (FS). Methods:  We measured and compared the serum or cerebrospinal fluid (CSF) levels of S100B, neuron specific enolase (NSE), and total tau protein in 43 patients with FS and 18 patients with AESD, at any point during the disease. To assess early diagnostic validity, we compared these biomarkers in 43 FS and 8 AESD patients, with whom the day 0-2 samples were available. We used the receiver operating characteristic (ROC) curve to evaluate the diagnostic values of these markers. Results and Conclusions:  The levels of all biomarkers were significantly higher in AESD than FS patients. When only days 0-2 samples from AESD patients were used, the levels of all the measured biomarkers, except serum NSE, were still significantly higher in patients with AESD than in FS, suggesting that AESD could damage astrocytes, neurons, and axons, even in the early stages of the disease. According to the ROC curve analyses, CSF S100B (cut-off value, 100 pg/ml) and CSF total tau protein (cut-off value, 100 pg/ml) were better predictors of AESD than other biomarkers, the combination of both resulted the positive predictive value for AESD 83.3%, could be helpful for early diagnosis, facilitating early therapeutic interventions.
Authors:
Takashi Shiihara; Taeko Miyake; Sakiko Izumi; Mio Watanabe; Keiko Kamayachi; Kazuhiko Kodama; Makoto Nabetani; Masako Ikemiyagi; Yoshio Yamaguchi; Noriko Sawaura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
Affiliation:
Department of Neurology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan Department of Laboratory Medicine, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa, Gunma 377-8577, Japan Department of Pediatrics, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan Department of Pediatrics, Mimihara General Hospital, 4-465 Kyouwa-Cho, Sakai-ku, Sakai-shi, Osaka 590-8505, Japan Department of Pediatrics, Yodogawa Christian Hospital, 2-9-26 Awaji, Higashiyodogawa-ku, Osaka-shi, Osaka 533-0032, Japan Department of Pediatrics, National Hospital Organization Saitama National Hospital, 2-1 Suwa, Wako-shi, Saitama 351-0102, Japan Institute of Clinical Research & Department of infection and allergy, National Hospital Organization Tochigi Hospital, 1-10-37 Nakatomaturi, Utunomiya, Tochigi 320-8580, Japan.
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