| Serum cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis or pancreatic steatorrhea. | |
| | |
MedLine Citation:
|
PMID: 3291084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We compared serum concentrations of cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis (and of pancreatic steatorrhea in the 41 patients with steatorrhea) in 105 patients (57 men, 48 women) consecutively investigated because of clinical suspicion of chronic pancreatitis. Chronic pancreatitis (36 patients), pancreatic steatorrhea (24 patients), and other diseases were diagnosed without knowledge of the serum levels of the three enzymes. When evaluated by means of receiver operating characteristic curves, no differences were found in diagnostic performance of the enzymes with regard to chronic pancreatitis or pancreatic steatorrhea. The sensitivity and specificity for recognition of chronic pancreatitis ranged from 0.306 to 0.444 and from 0.942 to 0.986 when the discrimination values were chosen to give highest efficiencies. The similar ranges for pancreatic steatorrhea were 0.500-0.708 and 0.882-0.941. In conclusion, none of the three enzymes had any advantage over the others as diagnostic tests of chronic pancreatitis or of pancreatic steatorrhea. Only positive test results have clinical importance because of the low sensitivities of the three enzymes. |
| | |
Authors:
|
J Møller-Petersen; J O Pedersen; N T Pedersen; B N Andersen |
Related Documents
:
|
1886894 - Association of malignant lymphoma with pancreatic adenocarcinoma: a clinicopathologic s... 10512104 - Autoimmune pancreatitis with f-18 fluoro-2-deoxy-d-glucose pet findings 9375084 - Telematic electrodiagnosis. 3308374 - Pancreatic abscess and infected pancreatic necrosis. different local septic complicatio... 10821014 - The thiazolidinediones or "glitazones" a treatment option for type 2 diabetes mellitus. 21896144 - β-adrenergic blockers. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 23 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1988 Apr |
Date Detail:
|
Created Date: 1988-08-03 Completed Date: 1988-08-03 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 287-96 Citation Subset: IM |
Affiliation:
|
Dept. of Medical Gastroenterology, Aalborg Hospital, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Celiac Disease / diagnosis, enzymology* Chronic Disease Clinical Trials as Topic Female Glycoside Hydrolases / metabolism* Humans Isoamylase / metabolism* Lipase / metabolism* Male Middle Aged Pancreas / enzymology Pancreatitis / diagnosis, enzymology* Trypsin / blood* |
| Chemical | |
Reg. No./Substance:
|
EC 3.1.1.3/Lipase; EC 3.2.1.-/Glycoside Hydrolases; EC 3.2.1.68/Isoamylase; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sleep-induced GH release in otherwise GH deficient children having short stature; a possibly new var...
Next Document: Cimetidine responders in non-ulcer dyspepsia.