Document Detail


Serum catalytic iron as a novel biomarker of vascular injury in acute coronary syndromes.
MedLine Citation:
PMID:  19736158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Catalytic iron is associated with high oxidative stress during vascular injury. We measured catalytic iron in patients with suspected acute coronary syndromes (ACS) and healthy volunteers to evaluate its utility in early detection of patients with acute myocardial infarction (MI) and predicting major adverse cardiac events (MACE). METHODS AND RESULTS: Catalytic iron was measured on admission and 24 hours later in 127 patients with acute MI, 51 patients with suspected ACS without MI, and 250 healthy volunteers. Descriptive and decision statistics were performed for catalytic iron and troponin I. Catalytic iron levels at presentation were 1.5+2.0 micromol/l, 0.2+0.16 micromol/l, and 0.1+0.06 micromol/l for acute MI, suspected ACS without MI, and normals, respectively p<0.0001. Catalytic iron was elevated in all patients with MI at presentation. At a cutpoint of 0.30 micromol/L, the sensitivity, specificity, and diagnostic accuracy for identifying MI was 84%, 95%, and 92%, respectively. Increase in catalytic iron at 24 hours compared to baseline was associated with MACE at 30 days. CONCLUSIONS: Catalytic iron identified all patients with acute MI at presentation and serial elevation was independently associated with MACE. This biomarker of vascular injury is useful in the rapid serologic assessment of patients with suspected ACS.
Authors:
Suhas Lele; Sudhir Shah; Peter A McCullough; Mohan Rajapurkar
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  5     ISSN:  1774-024X     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-08     Completed Date:  2009-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  336-42     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Bhailal Amin General Hospital, Baroda, India. lelesuhas@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*,  complications
Angina Pectoris / blood,  etiology
Biological Markers / blood
Case-Control Studies
Humans
Iron / blood*
Logistic Models
Myocardial Infarction / blood*,  etiology
Predictive Value of Tests
ROC Curve
Risk Assessment
Sensitivity and Specificity
Time Factors
Troponin I / blood
Up-Regulation
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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