Document Detail


Serum cartilage oligomeric matrix protein accumulation decreases significantly after 12 weeks of running but not swimming and cycling training - a randomised controlled trial.
MedLine Citation:
PMID:  22770506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acute effects of physical exercise on the deformational behaviour of articular cartilage and changes in cartilage oligomeric matrix protein (COMP) are definite. However, conclusive positive effects of fitness exercise on functional adaptation of articular cartilage have not been proved.
AIM: Therefore, in this parallel-group randomised controlled trial, we tested the hypothesis that adequate amount of physical exercise with enough impact would be able to stimulate the functional behaviour of articular cartilage.
METHODS: We evaluated 44 healthy males for their physical-fitness levels and their blood samples were obtained before, immediately after and 0.5h after a 30-min walking exercise. Thereafter, participants were assigned to the running, the cycling, the swimming and the control groups. At the end of 12weeks of intervention, the same measurement procedures were applied. Mixed repeated-measures analysis of variance (ANOVA) design was used for statistics. (
LEVEL OF EVIDENCE: 2).
RESULTS: Pre-test measurements showed that 30min of walking significantly increased serum-COMP levels in all groups. The post-tests revealed that the COMP level of all groups, except running, showed an increase after a 30-min walking activity.
CONCLUSION: Overall, it was concluded that, 12weeks of regular, weight-bearing, high-impact physical exercise (i.e., running) decreases the deformational effect of walking activity. This finding is an evidence of functional adaptation of articular cartilage to specific environmental requirements.
Authors:
Ozgur Celik; Yasar Salci; Emre Ak; Aydiner Kalaci; Feza Korkusuz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-07-05
Journal Detail:
Title:  The Knee     Volume:  20     ISSN:  1873-5800     ISO Abbreviation:  Knee     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-06-04     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9430798     Medline TA:  Knee     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bicycling / physiology*
Biological Markers / blood
Cartilage Oligomeric Matrix Protein
Cartilage, Articular / metabolism*
Enzyme-Linked Immunosorbent Assay
Exercise Test
Extracellular Matrix Proteins / blood*
Follow-Up Studies
Glycoproteins / blood*
Humans
Male
Matrilin Proteins
Prospective Studies
Reference Values
Running / physiology*
Swimming / physiology*
Time Factors
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cartilage Oligomeric Matrix Protein; 0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/Matrilin Proteins; 0/TSP5 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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