Document Detail


Serum carnitine levels in newborns with perinatal asphyxia and relation to neurologic prognosis.
MedLine Citation:
PMID:  15682932     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal hypoxic encephalopathy is one of the major causes of permanent neurological sequel. This study was conducted to investigate serum total, free and acylcarnitine levels in asphyxiated newborns with or without encephalopathy. Serum total, free and acylcarnitine levels were investigated in 21 newborns with and seven asphyxiated newborns without signs of encephalopathy. The newborns with encephalopathy were further divided into grade 1, 2 and 3 encephalopathy groups. Serum total and acylcarnitine concentrations of the whole encephalopathy group were significantly lower than the non-encephalopathy group (p = 0.042 for both). Serum total and acylcarnitine concentrations of grade 3 encephalopathy group were significantly lower than the non-encephalopathy group (p = 0.014 and p = 0.040, respectively). No significant differences were noticed for free carnitine levels. Total carnitine levels were positively correlated with birth weight and 10th minute apgar score, whereas acylcarnitine levels were found to correlate with cord blood pH and free carnitine levels with birth weight. Cord blood pH, and total carnitine levels were found to be the most significant determinants of the neurological outcome at one year of age. It was emphasized that carnitine deficiency could occur in severely affected asphyxiated newborns and it is related to the outcome at one year of age.
Authors:
F S Ezgü; Y Atalay; A Hasanoğlu; K Gücüyener; G Biberoğlu; E Koç; E Ergenekon; L Tümer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  7     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2004 Oct-Dec
Date Detail:
Created Date:  2005-02-01     Completed Date:  2005-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
Affiliation:
Department of Pediatric Metabolism, Faculty of Medicine, Gazi University, Beşevler, Ankara, Turkey. fatihezgu@isbank.net.tr
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MeSH Terms
Descriptor/Qualifier:
Apgar Score
Asphyxia Neonatorum / blood*
Birth Weight
Blood
Brain Diseases / blood
Carnitine / analogs & derivatives*,  blood*
Humans
Hydrogen-Ion Concentration
Infant, Newborn
Prognosis
Chemical
Reg. No./Substance:
0/acylcarnitine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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