| Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital. | |
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MedLine Citation:
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PMID: 9853647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum levels of free, acyl, and total carnitine were determined in 32 patients with seizures, before and after 3, 6, and 12 months of treatment with valproic acid (17 patients), carbamazepine (10 patients), or phenobarbital (5 patients). In all three treated groups, both free and total carnitine levels showed a significant decline with respect to pretreatment levels. This decline was most marked and most consistent in patients treated with valproic acid. In 35% of the patients in this group, carnitine deficiency (ie, total carnitine < 30 micromol/L) was observed by month 12. In none of the three groups were serum carnitine levels significantly correlated with the serum concentration of the drug. These findings suggest a need to monitor serum carnitine levels in children treated with any of these drugs. |
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Authors:
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M Castro-Gago; J Eirís-Puñal; M I Novo-Rodríguez; J Couceiro; F Camiña; S Rodríguez-Segade |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 13 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-03-05 Completed Date: 1999-03-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 546-9 Citation Subset: IM |
Affiliation:
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Departamento de Pediatría, Complejo Hospitalario Universitario de Santiago de Compostela, Hospital General de Galicia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Animals Anticonvulsants / therapeutic use* Carbamazepine / therapeutic use* Carnitine / blood* Child Child, Preschool Epilepsy / blood*, drug therapy* Humans Infant Phenobarbital / therapeutic use* Statistics, Nonparametric Valproic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 298-46-4/Carbamazepine; 50-06-6/Phenobarbital; 541-15-1/Carnitine; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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