| Serum cardiac troponin-I elevation in neonatal cardiac surgery is lesion-dependent. | |
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MedLine Citation:
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PMID: 16202896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Serum cardiac troponin-I (cTn-I) is a marker for myocardial injury in adults that undergoes developmental isoform change. To determine its utility as a myocardial injury marker in neonates, the authors examined the perioperative pattern of cTn-I elevation in neonates undergoing surgical repair for hypoplastic left-heart syndrome (HLHS) and transposition of great arteries (TGA). DESIGN: A prospective cohort study. SETTING: The study was performed in a tertiary teaching hospital that is a major referral center for congenital cardiac surgery. PATIENTS: Forty-five neonates were enrolled, 17 with HLHS, 15 with TGA with intact septum (TGA + IVS), 8 with TGA with ventricular septal defect (TGA + VSD), and 5 neonates undergoing extracardiac surgery who did not require cardiopulmonary bypass (CPB). INTERVENTIONS: None. RESULTS: Preoperative cTn-I was elevated in all neonates undergoing cardiac surgery with CPB. Increases in postoperative cTn-I correlated with duration of aortic cross-clamp application and CPB. Peak elevation in serum cTn-I occurred between 6 and 24 hours postoperatively in all neonates after cardiac surgery. The perioperative pattern of cTn-I was different in TGA + VSD (peak cTn-I = 10.9 +/- 5.9 ng/mL) compared with HLHS (peak cTn-I = 4.62 +/- 3.4 ng/mL) and TGA + IVS (peak cTn-I = 4.46 +/- 3.5 ng/mL). CONCLUSION: It was found that perioperative elevations in serum cTn-I in neonates with TGA and HLHS were influenced by duration of aortic cross-clamp application, CPB, and the presence of VSD. |
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Authors:
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Neeta R Saraiya; Lena S Sun; Amy E Jonassen; Michael A Pesce; Jan M Queagebeur |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 19 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-05 Completed Date: 2006-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 620-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Columbia University, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures* Cardiopulmonary Bypass Cardiotonic Agents / therapeutic use Creatine Kinase, MB Form / blood Female Heart Septal Defects, Ventricular / blood, therapy Humans Hypoplastic Left Heart Syndrome / blood, therapy Infant, Newborn Length of Stay Male Postoperative Complications / blood, etiology Predictive Value of Tests Prospective Studies Survival Analysis Time Factors Transposition of Great Vessels / blood, therapy Treatment Outcome Troponin I / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Troponin I; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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