Document Detail


Serum carboxyl-terminal propeptide of procollagen type I in exercise-induced left ventricular hypertrophy.
MedLine Citation:
PMID:  15346845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Left ventricular hypertrophy (LVH) induced by exercise is considered to be a physiologic adaptive mechanism without fibrogenic hyperactivity, as occurs in pathologic hypertrophy. HYPOTHESIS: This study investigated serum markers of collagen synthesis and echo parameters of left ventricular diastolic function (LVdf) in 22 male athletes. METHODS: Twenty-two highly competitive male athletes (10 cyclists, 12 soccer players) were studied with full history, clinical examination, Doppler echocardiogram, and serum concentration of the carboxyl-terminal propeptide of collagen type I (PIP). They were divided into two groups: normal left ventricular mass (N) with left ventricular mass index (LVMI) < 125 g/m2 (14 athletes) and LVH with LVMI > 125 g/m2 (8 athletes). RESULTS: Age, body surface area, blood pressure, heart rate, and systolic function were not different between the groups. Serum concentration of PIP (N: 163 +/- 44.1 microg/l, LVH: 172.7 +/- 61.2 microg/l--NS) and LVdf (early to atrial peak mitral flow velocity ratio: [E/A] N: 1.77 +/- 0.47, LVH: 1.98 +/- 0.70--NS, and early to atrial peak mitral annulus velocity ratio: [Ea/Aa] N: 2.63 +/- 0.70, LVMI: 2.55 +/- 0.90 LV 1.61--NS) were similar in both groups. CONCLUSIONS: Normal serum concentration of PIP in athletes with LVH in association with normal LVdf indicates the possibility that in this type of physiologic hypertrophy there is mainly an increase of myocyte size without interstitial fibrosis.
Authors:
Eduardo M Escudero; Ana L Tufare; Oscar Rebolledo; Laura Pellegrini; Carlos Lobrutto
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Publication Detail:
Type:  Clinical Conference; Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  27     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-06     Completed Date:  2004-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  IM    
Affiliation:
Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina. cardital@netverk.com.ar
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Collagen / analysis*
Collagen Type I / analysis*
Exercise / physiology*
Humans
Hypertrophy, Left Ventricular / physiopathology*
Linear Models
Male
Peptides / analysis*
Sports / physiology*
Ventricular Function, Left / physiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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