Document Detail


Serum carbenoxolone in patients with gastric and duodenal ulcer: Absorption, efficacy and side-effects.
MedLine Citation:
PMID:  648939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The absorption of carbenoxolone sodium has been studied in 15 patients with gastric ulcer and eight patients with duodenal ulcer treated for four weeks. Blood levels of carbenoxolone showed a log distribution, varied markedly between patients, and were significantly higher after Biogastrone tablets (300 mg/day) than after Duogastrone capsules (200 mg/day). Serum carbenoxolone levels were similar in patients taking Biogastrone tablets before or after meals, and in patients taking Biogastrone tablets or Duogastrone capsules with or without antacids following chronic administration. Serum carbenoxolone levels were similar in patients whose gastric ulcers had or had not healed after four weeks' treatment. Serum carbenoxolone was significantly higher in patients who developed oedema, and was significantly correlated with age and with fall in plasma potassium. Carbenoxolone may exert its metabolic effects systemically, but its ulcer-healing effects topically; additional studies are needed to test this hypothesis.
Authors:
J H Baron; J N Gribble; C Rhodes; P A Wright
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  19     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  330-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Antacids / pharmacology
Carbenoxolone / administration & dosage,  adverse effects,  blood*
Duodenal Ulcer / blood*
Edema / chemically induced
Female
Humans
Intestinal Absorption
Male
Middle Aged
Stomach Ulcer / blood*
Triterpenes / blood*
Wound Healing
Chemical
Reg. No./Substance:
0/Antacids; 0/Triterpenes; 5697-56-3/Carbenoxolone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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