Document Detail

Serum cancer antigen 125 in patients with pleural effusions.
MedLine Citation:
PMID:  17623956     Owner:  NLM     Status:  MEDLINE    
We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included in the study. There were no significant differences in age, gender and ethnicity of the patients with benign and malignant effusions. There was also no difference in the frequency of the side of pleural effusion between the two groups but compared to benign effusions, a higher proportion of malignant effusions was moderate to large in size (66% versus 39%, p = 0.011). Serum CA125 levels were above 35U/dL in 83.3% and 78.1% of patients with malignant and benign effusions, respectively (p = 0.532). All patients with underlying malignancy and 95.3% of patients with benign effusions had pleural fluid CA125 levels above 35U/dL (p = 0.187). The median levels of CA125 were higher in the pleural fluid than in the serum in all aetiological groups. Higher serum CA125 levels were more likely to be found in patients with moderate to large effusions (p = 0.015), malignant effusions (p = 0.001) and in female patients (0.016). Serum CA125 level showed significant correlation with pleural fluid CA125 level (r = 0.532, p < 0.001) but not with pleural fluid total white blood cell count (r = -0.092, p = 0.362), red blood cell count (r = -0.082, p = 0.417) and lactate dehydrogenase level (r = 0.062, p = 0.541). We conclude that serum CA125 is commonly elevated in patients with benign and malignant pleural effusions.
S H How; C K Liam; A R Jamalludin; S P Chin; A B Zal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Medical journal of Malaysia     Volume:  61     ISSN:  0300-5283     ISO Abbreviation:  Med. J. Malaysia     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-07-12     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361547     Medline TA:  Med J Malaysia     Country:  Malaysia    
Other Details:
Languages:  eng     Pagination:  558-63     Citation Subset:  IM    
Department of Internal Medicine, Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia, Jalan Hospital, 25150 Kuantan, Pahang Darull Makmur, Malaysia.
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MeSH Terms
Biological Markers
CA-125 Antigen / blood*
Malaysia / epidemiology
Middle Aged
Neoplasms / blood*,  physiopathology
Pleural Effusion / blood*,  epidemiology,  etiology
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/CA-125 Antigen

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