Document Detail

Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans.
MedLine Citation:
PMID:  20448635     Owner:  NLM     Status:  MEDLINE    
Sub-Saharan Africans face an increasing burden of hypertension. Although controversial, recent experimental evidence strongly suggests that serum calcium contributes to elevated blood pressure through increased vascular resistance. We investigated the associations of 24-h blood pressure and cardiovascular reactivity with serum calcium in African men stratified by age. The study consisted of 50 younger (median age: 38 years) and 49 older (median age: 49 years) participants. We measured 24-h ambulatory blood pressure with a mean successful inflation rate of 72.6%. Total peripheral resistance and stroke volume reactivity were obtained using a Finometer device during application of the Stroop color and word conflict test. Total serum calcium was adjusted for serum albumin. Results showed that serum calcium levels were similar between the younger and older groups. However, in the younger group, 24-h systolic blood pressure, 24-h diastolic blood pressure and total peripheral resistance reactivity correlated positively, whereas stroke volume reactivity correlated negatively with serum calcium in single and multiple regression analyses (systolic blood pressure: B=34.99, P=0.017; diastolic blood pressure: B=34.93, P<0.001; total peripheral resistance reactivity: B=65.44, P=0.048; stroke volume reactivity: B=-45.40, P=0.017). No associations were evident in the older African men. In conclusion, 24-h ambulatory systolic and diastolic blood pressures are positively associated with serum calcium in African men younger than 43 years. The blood pressure-serum calcium relationship seems to be mediated through increased vascular resistance during stress.
Rudolph Schutte; Hugo W Huisman; Aletta E Schutte; Nicolaas T Malan; Johannes M van Rooyen; Carla Mt Fourie; Leoné Malan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-07
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  33     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  688-94     Citation Subset:  IM    
Hypertension in Africa Research Team (HART), School for Physiology, Nutrition, and Consumer Sciences, North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
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MeSH Terms
African Continental Ancestry Group
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory*
Calcium / blood*
Cross-Sectional Studies
Middle Aged
South Africa
Stroke Volume / physiology
Vascular Resistance*
Reg. No./Substance:

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