Document Detail


Serum calcium and parathyroid hormone during the reproductive cycle in normal and vitamin D-deficient rats.
MedLine Citation:
PMID:  7056226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to investigate the ability of the vitamin D-deficient (-D) rat to maintain calcium (Ca) homeostasis during pregnancy. Serum Ca and immunoreactive parathyroid hormone (iPTH) were measured before and during pregnancy and after lactation in normal (+D) and -D rats. Serum Ca increased from 9.4 +/- 0.3 to 10.2 +/- 0.2 mg/dl during the first 3 days of pregnancy in +D animals and then declined throughout the remainder of gestation to 9.7 mg/dl at 17 days of gestation. In contrast, serum Ca rose progressively during the first 17 days of pregnancy in -D rats from 5.5 +/- 0.2 to 6.7 +/- 0.4 mg/dl. As expected, the -D rats had markedly elevated serum iPTH, but there were no changes in circulating iPTH during pregnancy in either animal model, even though serum Ca increased significantly during pregnancy in -D animals and Ca decreased in the +D rats. After lactation, serum Ca of -D rats increased 2 mg/dl before returning to prepregnancy levels. These results suggest that there are physiological mechanisms which appear to be independent of vitamin D and are responsible for elevating serum Ca during pregnancy and lactation.
Authors:
M L Thomas; L R Forte
Related Documents :
11739006 - Temporally regulated overexpression of parathyroid hormone-related protein in the mamma...
20051486 - Pregnancy up-regulates intestinal calcium absorption and skeletal mineralization indepe...
12730486 - Micronutrients and the bone mineral content of the mother, fetus and newborn.
11832996 - Hepatocyte growth factor in human breast milk acts as a trophic factor.
7944126 - Presence of cells of fetal origin in maternal circulation of pregnant women.
12535386 - Instruments for chorionic villus sampling for prenatal diagnosis.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  110     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  703-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / blood*
Female
Lactation
Parathyroid Hormone / blood*
Pregnancy
Pregnancy, Animal*
Rats
Rats, Inbred Strains
Vitamin D Deficiency / physiopathology*
Grant Support
ID/Acronym/Agency:
AM-06148/AM/NIADDK NIH HHS; AM-14787/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The decrease in hypothalamic dopamine secretion induced by suckling: comparison of voltammetric and ...
Next Document:  An alternative approach to the quantitation of glucocorticoid-receptor complexes in the nuclei of ly...