Document Detail

Serum calcium and parathyroid hormone during the reproductive cycle in normal and vitamin D-deficient rats.
MedLine Citation:
PMID:  7056226     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate the ability of the vitamin D-deficient (-D) rat to maintain calcium (Ca) homeostasis during pregnancy. Serum Ca and immunoreactive parathyroid hormone (iPTH) were measured before and during pregnancy and after lactation in normal (+D) and -D rats. Serum Ca increased from 9.4 +/- 0.3 to 10.2 +/- 0.2 mg/dl during the first 3 days of pregnancy in +D animals and then declined throughout the remainder of gestation to 9.7 mg/dl at 17 days of gestation. In contrast, serum Ca rose progressively during the first 17 days of pregnancy in -D rats from 5.5 +/- 0.2 to 6.7 +/- 0.4 mg/dl. As expected, the -D rats had markedly elevated serum iPTH, but there were no changes in circulating iPTH during pregnancy in either animal model, even though serum Ca increased significantly during pregnancy in -D animals and Ca decreased in the +D rats. After lactation, serum Ca of -D rats increased 2 mg/dl before returning to prepregnancy levels. These results suggest that there are physiological mechanisms which appear to be independent of vitamin D and are responsible for elevating serum Ca during pregnancy and lactation.
M L Thomas; L R Forte
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  110     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  703-7     Citation Subset:  AIM; IM    
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MeSH Terms
Calcium / blood*
Parathyroid Hormone / blood*
Pregnancy, Animal*
Rats, Inbred Strains
Vitamin D Deficiency / physiopathology*
Grant Support
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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