Document Detail

Serum calcium and magnesium in schizophrenia: relationship to clinical phenomena and neuroleptic treatment.
MedLine Citation:
PMID:  354732     Owner:  NLM     Status:  MEDLINE    
Serum calcium and magnesium were studied in drug-free and neuroleptic-treated schizophrenic patients. Calcium and magnesium were not significantly different in 31 unmedicated schizophrenic patients compared with normal controls. Serum calcium was altered, however, in two subgroups: (1) Patients who remitted after neuroleptic withdrawal were significantly lower in calcium than those who did not remit; (2) catatonic schizophrenic patients appeared to have an increased calcium at the onset of catatonic stupor. Patients treated with pimozide were found to have a significant decreased in both calcium and magnesium compared with their drug-free values. These same patients showed a similar decrease in both electrolytes during treatment with fluphenazine, a structurally different neuroleptic drug.
P E Alexander; D P Van Kammen; W E Bunney
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  133     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
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MeSH Terms
Calcium / blood*
Clinical Trials as Topic
Double-Blind Method
Magnesium / blood*
Middle Aged
Remission, Spontaneous
Schizophrenia / blood*,  drug therapy
Tranquilizing Agents / therapeutic use*
Reg. No./Substance:
0/Tranquilizing Agents; 7439-95-4/Magnesium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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