Document Detail


Serum bile acids in newborns and children.
MedLine Citation:
PMID:  7454436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A specific and sensitive radioimmunoassay for cholic, chenodeoxycholic, and lithocholic acid conjugates and for sulfolithocholylglycine was used to measure serum bile acids (BA) in infants and children. Elevated cholic and chenodeoxycholic acid values were observed in the first year of life in fasting infants. Newborn babies presented high levels of primary BA not correlated with those of the mothers. In premature newborn babies who had not yet been fed, meal induced a considerable reduction in the primary BA levels in serum. In normally fed babies, meal induced a significant increase in the primary BA levels in serum. These data suggest a progressive maturity throughout the first year of life of the serum BA determinants, i.e., gallbladder emptying, intestinal motility and absorption, and hepatic uptake.
Authors:
L Barbara; R Lazzari; A Roda; R Aldini; D Festi; C Sama; A M Morselli; A Collina; F Bazzoli; G Mazzella; E Roda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  14     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1222-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bile Acids and Salts / blood*
Chenodeoxycholic Acid / blood
Child
Child, Preschool
Cholic Acids / blood
Eating
Fasting
Female
Glycocholic Acid / analogs & derivatives,  blood
Humans
Infant
Infant, Newborn
Infant, Premature
Lithocholic Acid / analogs & derivatives,  blood
Male
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 15324-64-8/sulfolithocholylglycine; 434-13-9/Lithocholic Acid; 474-25-9/Chenodeoxycholic Acid; 475-31-0/Glycocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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