| Serum bile acid concentrations in the course of benign recurrent intrahepatic cholestasis. | |
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MedLine Citation:
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PMID: 7259083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The patient reported here represents the classic features of the syndrome of benign recurrent intrahepatic cholestasis (BRIC). She had conjugated hyperbilirubinaemia during the neonatal period and early infancy. The concentrations of serum primary bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA) were determined by radioimmunoassay and were continuously extremely raised during the icteric, recovery, and also the anicteric phases of the disease. The ratio of CA to CDCA was always within the normal range. The secondary serum bile acid, deoxycholic acid (DCA), was only slightly raised. The oral cholate tolerance test was abnormal in the patient during the anicteric phase. These observations support the suggestion that a disturbance of the hepatocellular bile acid transport may be the primary defect in BRIC. |
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Authors:
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K Finni; S Similä; S Heikura; O Jänne; O Mäentausta |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of clinical research Volume: 12 ISSN: 0003-4762 ISO Abbreviation: Ann. Clin. Res. Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1981-09-15 Completed Date: 1981-09-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0220042 Medline TA: Ann Clin Res Country: FINLAND |
Other Details:
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Languages: eng Pagination: 168-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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blood* Chenodeoxycholic Acid / blood Cholestasis, Intrahepatic / blood*, complications Cholic Acids / blood Female Humans Hyperbilirubinemia / complications Infant, Newborn Radioimmunoassay Recurrence |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholic Acids; 474-25-9/Chenodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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