Document Detail


Serum bicarbonate and mortality in adults in NHANES III.
MedLine Citation:
PMID:  23348878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Low serum bicarbonate concentration is a risk factor for death in people with chronic kidney disease (CKD). Whether low serum bicarbonate is a mortality risk factor for people without CKD is unknown.
METHODS: National Health and Nutrition Examination Survey III (NHANES III) adult participants were categorized into one of four serum bicarbonate categories: <22, 22-25, 26-30 and ≥ 31 mM. Cox models were used to determine the hazards of death in each serum bicarbonate category, using 26-30 mM as the reference group, in the (i) entire population, (ii) non-CKD subgroup and (iii) CKD subgroup.
RESULTS: After adjusting for age, gender, race, estimated glomerular filtration rate, albuminuria, diuretic use, smoking, C-reactive protein, cardiovascular disease, protein intake, diabetes, hypertension, body mass index, lung disease and serum albumin, the hazards of death in the <22 mM serum bicarbonate category were 1.75 (95% CI: 1.12-2.74), 1.56 (95% CI: 0.78-3.09) and 2.56 (95% CI: 1.49-4.38) in the entire population, non-CKD subgroup and CKD subgroup, respectively, compared with the reference group. Hazard ratios in the other serum bicarbonate categories in the entire population and non-CKD and CKD subgroups did not differ from the reference group.
CONCLUSIONS: Among the NHANES III participants, low serum bicarbonate was not observed to be a strong predictor of mortality in people without CKD. However, low serum bicarbonate was associated with a 2.6-fold increased hazard of death in people with CKD.
Authors:
Kalani L Raphael; Yingying Zhang; Guo Wei; Tom Greene; Alfred K Cheung; Srinivasan Beddhu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-24
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  28     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2013-12-10     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  1207-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Albuminuria / blood,  mortality*
Bicarbonates / blood*
Biological Markers / blood*
Body Mass Index
Cardiovascular Diseases / blood,  mortality*
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Male
Middle Aged
Nutrition Surveys
Prognosis
Renal Insufficiency, Chronic / blood,  mortality*
Risk Factors
Survival Rate
Grant Support
ID/Acronym/Agency:
1 KM1CA156723/CA/NCI NIH HHS; 5TL1RR025762-03/RR/NCRR NIH HHS; C06-RR11234/RR/NCRR NIH HHS; R01DK077298/DK/NIDDK NIH HHS; R01DK078112/DK/NIDDK NIH HHS; UL1-RR025764/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Biological Markers
Comments/Corrections

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