| Serum beta human chorionic gonadotropin levels at 16 days following embryo transfer in intra cytoplasmic sperm injection cycles to predict pregnancy outcome. | |
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MedLine Citation:
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PMID: 20844814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the prognostic value of beta human chorionic gonadotropin (B-hCG) concentration on the sixteenth day after embryo transfer to predict pregnancy outcome. METHODS: In this retrospective cohort study, B-hCG levels were measured in 97 pregnant women that underwent intra-cytoplasmic sperm injection (ICSI) in Fatemeh-Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran from January 2008 to December 2009. Type, duration, causes of infertility, and age of patients, B-hCG levels on the sixteenth day after embryo transfer, the number of embryos, and pregnancy outcome were assessed. RESULTS: Incidence of viable pregnancies in B-hCG levels less than 100 IU/L (n=18) was 38.9%, and in B-hCG levels more than or equal to 100 IU/L (n=79) was 84.4%. Correlation of B-hCG with pregnancy outcome was significant (p less than 0.001). Cut-off value of B-hCG to predict viable pregnancy was 100 IU/L (sensitivity - 91%, specificity - 48%, PPV - 85%, and NPV - 61%). The B-hCG levels less than or equal to 200 IU/L with a sensitivity of 88%, specificity of 45%, PPV - 37%, and NPV = 91% had predicted twin pregnancy. CONCLUSION: Serum B-hCG level on the sixteenth day after embryo transfer can be useful to predict the pregnancy outcome in ICSI cycles. |
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Authors:
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Zahra Basirat; Ali Bijani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi medical journal Volume: 31 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 1015-20 Citation Subset: IM |
Affiliation:
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Fatemeh-Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, PO Box 4719173716, Babol, Iran. Zahra_Basirat@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Chorionic Gonadotropin, beta Subunit, Human / blood* Embryo Transfer* Female Humans Infertility / therapy Male Predictive Value of Tests Pregnancy Pregnancy Outcome* Retrospective Studies Sensitivity and Specificity Sperm Injections, Intracytoplasmic* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin, beta Subunit, Human |
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