| Serum beta-human chorionic gonadotropin, estradiol and progesterone as early predictors of pathologic pregnancy. | |
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MedLine Citation:
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PMID: 1373448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We prospectively studied 110 asymptomatic female infertility patients with serial serum measures of beta-human chorionic gonadotropin (hCG), estradiol (E2) and progesterone (P) to determine their sensitivity, specificity, predictive value and test efficiency, alone or in combination, for the prediction of pathologic gestations prior to five weeks after ovulation. Circulating levels of serum beta-hCG, E2 and P were measured at 48- or 72-hour intervals. Seventy-four patients (67%) had viable pregnancies, for which the abnormal changes in steroid levels were defined as: a beta-hCG rise of less than 66% in 48 hours or less than 120% in 72 hours, an E2 decline of greater than 15% in 48 hours or greater than 20% in 72 hours, or a P decline of greater than 25% in 48 hours or greater than 33% in 72 hours. Thirty-six women (33%) had pathologic pregnancies, which included ectopic pregnancies (8), spontaneous or missed abortions (7), blighted ova (anembryonic gestation, 20) and hydatidiform mole (1). For the detection of pathologic pregnancies in this asymptomatic infertility population, the sensitivity of beta-hCG, E2 and P, singly or in combination, ranged from 34% to 78%, and the test efficiency ranged from 68% to 88%. Beta-hCG alone provided the highest sensitivity (78%) and test efficiency (88%). When compared to measuring serial beta-hCG alone, serum E2 or P did not enhance the test efficiency and lowered the sensitivity for the detection of pathologic pregnancies in an asymptomatic infertility population. |
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Authors:
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R P Buyalos; L M Glassman; S M Rifka; R J Falk; P O Macarthy; V J Tyson; M DiMattina |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 37 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-21 Completed Date: 1992-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 261-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, D.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / blood* Chorionic Gonadotropin, beta Subunit, Human District of Columbia / epidemiology Estradiol / blood* False Negative Reactions False Positive Reactions Female Hospitals, University Humans Incidence Peptide Fragments / blood* Pregnancy Pregnancy Complications / blood, epidemiology* Pregnancy Trimester, First Progesterone / blood* Prospective Studies Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments; 50-28-2/Estradiol; 57-83-0/Progesterone |
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