Document Detail

Serum beta-human chorionic gonadotropin, estradiol and progesterone as early predictors of pathologic pregnancy.
MedLine Citation:
PMID:  1373448     Owner:  NLM     Status:  MEDLINE    
We prospectively studied 110 asymptomatic female infertility patients with serial serum measures of beta-human chorionic gonadotropin (hCG), estradiol (E2) and progesterone (P) to determine their sensitivity, specificity, predictive value and test efficiency, alone or in combination, for the prediction of pathologic gestations prior to five weeks after ovulation. Circulating levels of serum beta-hCG, E2 and P were measured at 48- or 72-hour intervals. Seventy-four patients (67%) had viable pregnancies, for which the abnormal changes in steroid levels were defined as: a beta-hCG rise of less than 66% in 48 hours or less than 120% in 72 hours, an E2 decline of greater than 15% in 48 hours or greater than 20% in 72 hours, or a P decline of greater than 25% in 48 hours or greater than 33% in 72 hours. Thirty-six women (33%) had pathologic pregnancies, which included ectopic pregnancies (8), spontaneous or missed abortions (7), blighted ova (anembryonic gestation, 20) and hydatidiform mole (1). For the detection of pathologic pregnancies in this asymptomatic infertility population, the sensitivity of beta-hCG, E2 and P, singly or in combination, ranged from 34% to 78%, and the test efficiency ranged from 68% to 88%. Beta-hCG alone provided the highest sensitivity (78%) and test efficiency (88%). When compared to measuring serial beta-hCG alone, serum E2 or P did not enhance the test efficiency and lowered the sensitivity for the detection of pathologic pregnancies in an asymptomatic infertility population.
R P Buyalos; L M Glassman; S M Rifka; R J Falk; P O Macarthy; V J Tyson; M DiMattina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  37     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, D.C.
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MeSH Terms
Chorionic Gonadotropin / blood*
Chorionic Gonadotropin, beta Subunit, Human
District of Columbia / epidemiology
Estradiol / blood*
False Negative Reactions
False Positive Reactions
Hospitals, University
Peptide Fragments / blood*
Pregnancy Complications / blood,  epidemiology*
Pregnancy Trimester, First
Progesterone / blood*
Prospective Studies
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments; 50-28-2/Estradiol; 57-83-0/Progesterone

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