Document Detail

Serum beta-glucuronidase in subtypes of leprosy.
MedLine Citation:
PMID:  2345017     Owner:  NLM     Status:  MEDLINE    
Serum beta-glucuronidase activity was estimated using phenolphthalein mono-beta-glucuronic acid as substrate in 176 individuals including 72 lepromatous leprosy patients, 24 patients of borderline leprosy, 42 of borderline tuberculoid and 38 healthy controls. Of these, 35 patients (20 with lepromatous leprosy, 5 with borderline leprosy and 10 with borderline tuberculoid) were untreated. The enzyme levels were increased significantly in all types of leprosy, the highest levels being seen in treated lepromatous leprosy patients (105.0 SU). There was also a significant difference in the enzyme activity between untreated patients and those on combined dapsone and rifampicin therapy, in all three types of leprosy. Among untreated patients, the maximum value observed in lepromatous leprosy was 93.4 SU. The lowest enzyme level in healthy control was 19.5 SU and the maximum was 54.0 SU. The results suggest that in leprosy patients, especially in those on daily multidrug regimens, there is an extensive damage of leucocytes and liver cells where the enzyme is largely present.
J George; M Rajendran; V N Bhatia
Related Documents :
2952697 - Neurofunctional assessment of lateralized hemispheric asymmetries in affective illness.
6811517 - Hla-dr-associated genetic control of the type of leprosy in a population from surinam.
4032327 - Somatic illness in manic-depressive and schizophrenic patients.
17448257 - Metabolic syndrome in thai schizophrenic patients: a naturalistic one-year follow-up st...
24445157 - Evaluation of nested polymerase chain reaction for the early detection of leptospira sp...
20580567 - Serum cd44 levels predict survival in patients with low-risk myelodysplastic syndromes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  91     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
Central Leprosy Teaching & Research Institute, Chengalpattu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Glucuronidase / blood*
Leprosy / enzymology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Splenic natural cytotoxic activity is enhanced during growth of a murine fibrosarcoma.
Next Document:  Specific immune responses in typhoid fever & after TAB vaccination.