Document Detail


Serum beta-glucuronidase in subtypes of leprosy.
MedLine Citation:
PMID:  2345017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum beta-glucuronidase activity was estimated using phenolphthalein mono-beta-glucuronic acid as substrate in 176 individuals including 72 lepromatous leprosy patients, 24 patients of borderline leprosy, 42 of borderline tuberculoid and 38 healthy controls. Of these, 35 patients (20 with lepromatous leprosy, 5 with borderline leprosy and 10 with borderline tuberculoid) were untreated. The enzyme levels were increased significantly in all types of leprosy, the highest levels being seen in treated lepromatous leprosy patients (105.0 SU). There was also a significant difference in the enzyme activity between untreated patients and those on combined dapsone and rifampicin therapy, in all three types of leprosy. Among untreated patients, the maximum value observed in lepromatous leprosy was 93.4 SU. The lowest enzyme level in healthy control was 19.5 SU and the maximum was 54.0 SU. The results suggest that in leprosy patients, especially in those on daily multidrug regimens, there is an extensive damage of leucocytes and liver cells where the enzyme is largely present.
Authors:
J George; M Rajendran; V N Bhatia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  91     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
Affiliation:
Central Leprosy Teaching & Research Institute, Chengalpattu.
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MeSH Terms
Descriptor/Qualifier:
Female
Glucuronidase / blood*
Humans
Leprosy / enzymology*
Male
Chemical
Reg. No./Substance:
EC 3.2.1.31/Glucuronidase

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