Document Detail


Serum beta-amyloid correlates with neuropsychological impairment.
MedLine Citation:
PMID:  18923961     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Evidence suggests a relationship between peripheral Abeta and AD. We hypothesized that higher levels of serum Abeta(1-42) would be associated with memory impairment, thought to occur early in the disease, and rises in serum Abeta(1-40), which occur later, would be associated with impairment in non-memory measures. METHODS: Using a cross-sectional design, we examined the relationship of serum Abeta(1-40), Abeta(1-42), and the ratio of Abeta(1-42/1-40) to neuropsychological measures in 40 cognitively normal controls, 13 MCI subjects, and 25 AD patients. RESULTS: Serum Abeta(1-42) and the ratio of Abeta(1-42/1-40) were significantly higher in the MCI group compared to the controls. A significant relationship in the hypothesized direction (poorer scores associated with higher Abeta(1-40) serum levels) was found between Abeta(1-40) and measures of executive functions across the entire cohort of individuals tested and with measures of language and processing speed in the AD group. Regression analysis found that neuropsychological measures accounted for 26% of the variance in serum Abeta(1-40,) in the MCI/AD but not the controls. Furthermore that language and executive measures were significant predictors. CONCLUSIONS: Results provide preliminary data to partially support our hypotheses and suggest that changes in serum Abeta levels may be attributed to pathological changes within the brain.
Authors:
Cheryl A Luis; Laila Abdullah; Daniel Paris; Amita Quadros; Myles Mullan; Benoit Mouzon; Ghania Ait-Ghezala; Fiona Crawford; Michael Mullan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition     Volume:  16     ISSN:  1744-4128     ISO Abbreviation:  Neuropsychol Dev Cogn B Aging Neuropsychol Cogn     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-02     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9614434     Medline TA:  Neuropsychol Dev Cogn B Aging Neuropsychol Cogn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-18     Citation Subset:  IM    
Affiliation:
Roskamp Institute, Sarasota, FL, USA. cluis@rfdn.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / blood*
Amyloid beta-Protein / blood*
Analysis of Variance
Cognition Disorders / blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Language
Male
Memory Disorders / blood*
Neuropsychological Tests
Peptide Fragments / blood*
Regression Analysis
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Peptide Fragments; 0/amyloid beta-protein (1-40); 0/amyloid beta-protein (1-42)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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