Document Detail


Serum basic fibroblast growth factor levels in patients with ischemic heart disease.
MedLine Citation:
PMID:  9158164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Being a potent promoter of endothelial and smooth muscle cell proliferation, basic fibroblast growth factor (bFGF) is presumed to play a key role in coronary collateral development and atherogenesis. PURPOSE: To characterize serum bFGF levels in patients with ischemic heart disease. METHODS: The study population consisted of patients with angina (n=33) and after uncomplicated myocardial infarction (n=12). The number of significantly stenosed (> or = 50%) vessels and angiographic coronary collateral score were noted. Blood was drawn immediately prior to elective coronary angiography in study patients for bFGF levels. Twenty healthy, age-matched subjects served as control for serum bFGF. RESULTS: Serum bFGF levels were undetectable in all 20 control subjects, but were detectable in 15/33 (45%) patients with angina and 3/12 (25%) post-infarction patients, respectively (P=0.002). Serum bFGF levels were detectable in 13/23 (57%) patients with 0- or 1-vessel disease, as compared with 5/22 (23%) patients with 2- or 3-vessel disease (P<0.05). Detectable serum bFGF levels were not in correlation with coronary collateral score (P=1). CONCLUSIONS: Serum levels of bFGF are elevated in patients with ischemic heart disease, particularly in those with minimal coronary artery disease. We postulate that detectable serum bFGF levels reflect active atherogenesis rather than myocardial collateral development.
Authors:
D Hasdai; V Barak; E Leibovitz; I Herz; S Sclarovsky; M Eldar; M Scheinowitz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  59     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-10     Completed Date:  1997-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Beilinson Medical Center, Tel-Aviv University, Petah Tikva, Israel.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / blood
Arteriosclerosis / blood,  etiology
Case-Control Studies
Cell Division
Collateral Circulation / physiology
Coronary Angiography
Coronary Artery Disease / blood,  etiology
Coronary Circulation / physiology
Coronary Disease / blood,  radiography
Endothelium, Vascular / cytology
Female
Fibroblast Growth Factor 2 / blood*,  physiology
Humans
Male
Middle Aged
Muscle, Smooth, Vascular / cytology
Myocardial Infarction / blood
Myocardial Ischemia / blood*
Chemical
Reg. No./Substance:
103107-01-3/Fibroblast Growth Factor 2

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