Document Detail


Serum autoantibodies in systemic lupus erythematosus and correlation with cutaneous features.
MedLine Citation:
PMID:  6981704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eighty-eight untreated systemic lupus erythematosus patients collected from rheumatology services were studied for the presence of discoid, molar and vasculitic lesions and photosensitivity. Their sera were examined for antibodies to native deoxyribonucleic acid (nDNA), nuclear ribonuclear protein (nRNP), the non-nucleic acid nuclear macromolecule Sm, the nuclear and cytoplasmic macromolecules La(SSB) and the predominantly cytoplasmic macromolecule Ro(SSA). These studies demonstrated that 42% of the lupus patients possessed nDNA; 36% nRNP; 24% Ro(SSA) and 9% anti La(SSB) antibodies. Six patients failed to demonstrate significant antinuclear antibody titers (mouse liver substrate), and 4 of these possessed anti Ro(SSA) antibodies. Correlation to the cutaneous lesions among this lupus population possessing various serum antibodies revealed a trend toward photosensitivity and molar dermatitis in the Ro(SSA), La(SSB), Ro/la and the ANA negative, ANA negative/Ro positive groups of lupus patients.
Authors:
D R Synkowski; M Reichlin; T T Provost
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  9     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  380-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear / analysis
Autoantibodies / analysis*
DNA / immunology
Female
Humans
Lupus Erythematosus, Systemic / immunology*,  pathology
Male
Ribonucleoproteins / immunology
Skin / pathology
Grant Support
ID/Acronym/Agency:
1K08 AM00917-01, 5K04 AM00524-02/AM/NIADDK NIH HHS; 5R01 AM25650-04/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Ribonucleoproteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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