Document Detail


Serum atrial natriuretic peptide levels in infants with transient tachypnea of the newborn.
MedLine Citation:
PMID:  16076624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The mechanisms responsible for lung liquid clearance during the neonatal period result in switching of the lung epithelium from net secretion to net absorption following birth and driven by active Na(+) absorption. Transient tachypnea of the newborn (TTN) is known as the most common consequence of inadequate neonatal lung liquid clearance. It has been reported that alveolar type II cells behaved as a target for atrial natriuretic peptide (ANP) which inhibits the amiloride-sensitive Na-channel activity. The objective of this study is to investigate serum ANP concentrations in infants with TTN. METHODS: Fourteen newborn infants who were diagnosed with TTN (gestational age; 35.6 +/- 2.0 weeks) and twenty healthy neonates (gestational age; 36.3 +/- 2.2 weeks) were included in the study. Serum pro ANP concentrations were measured by ELISA using Biomedica GmbH (AUSTRIA) proANP kit on the 4th and 72nd hours of life. RESULTS: The mean serum pro ANP concentration was 2996 fmol/ml at 4 and 2694 fmol/ml at 72 hours of age for the infants with TTN and mean serum pro ANP concentrations of healthy infants found 3301 fmol/ml (p = 0.34) and 3204 fmol/ml (p = 0.04), respectively. CONCLUSION: It is concluded that serum ANP concentrations decreased in infants with TTN.
Authors:
E Esra Onal; Uğur Dilmen; Bahattin Adam; Canan Türkyilmaz; Füsun Kitapçi Uysal; Deniz Oğuz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  17     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-08-03     Completed Date:  2005-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
Affiliation:
Division of Neonatology, Gazi University Medical School, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Atrial Natriuretic Factor / blood*
Female
Humans
Infant, Newborn
Male
Respiratory Distress Syndrome, Newborn / blood*,  physiopathology
Chemical
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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