Document Detail

Serum and aortic lipid profiles in spontaneous and cholesterol-induced atherosclerosis in Rhesus monkeys.
MedLine Citation:
PMID:  1156469     Owner:  NLM     Status:  MEDLINE    
Serum lipids and lipoproteins and various lipid fractions in the aorta were compared in spontaneously-occurring and cholesterol-induced atherosclerosis of rhesus monkeys. A group of 30 normal monkeys were also studied. Serum cholesterol, total phospholipid and triglyceride values in spontaneous atherosclerosis were similar to normal, but were significantly elevated in cholesterol-induced atherosclerosis. Fractionation of the major phospholipids in animals with spontaneous atherosclerosis showed increased PC with decreased LPC and SP + LPE, while PE was elevated and SP + LPE diminished in cholesterol-induced atherosclerosis. Beta-lipoproteins were markedly increased in cholesterol-induced atherosclerosis, but remained normal in spontaneous atherosclerosis. Among the aortic lipid, PC and PE were significantly elevated in spontaneous atherosclerosis, but in cholesterol-induced atherosclerosis all the neutral lipids were raised, together with a specific rise of PC and decrease of SP + LPE. These observations tend to indicate that the mechanism of atherosclerosis production in the two states greatly varies.
A P Mohan; R N Chakravarti
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  22     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:    1975 Jul-Aug
Date Detail:
Created Date:  1975-11-01     Completed Date:  1975-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
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MeSH Terms
Aorta / metabolism*,  pathology
Arteriosclerosis / metabolism*,  pathology
Cholesterol / blood
Chromatography, Thin Layer
Diet, Atherogenic
Lipid Metabolism*
Lipids / blood
Lipoproteins / metabolism
Macaca mulatta
Phospholipids / blood,  metabolism
Triglycerides / blood,  metabolism
Reg. No./Substance:
0/Lipids; 0/Lipoproteins; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol

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