Document Detail


Serum antibodies to pneumococcal C polysaccharide in children: response to acute pneumococcal otitis media or to vaccination.
MedLine Citation:
PMID:  3615065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunoglobulin class-specific antibody responses to the pneumococcal C polysaccharide (CPS) and to the capsular polysaccharides of types 3, 6A, 18C and 19F were measured by enzyme-linked immunosorbent assay in the sera of children ages 6 months to 7 years. Twenty of these children had acute otitis media caused by pneumococci of type/group 3, 6, 18 or 19, whereas 20 received an injection of 14-valent pneumococcal capsular polysaccharide vaccine. Many of the children in both groups had large concentrations of IgG and/or IgM class anti-CPS antibodies in their first serum sample. Both the infection and the vaccine elicited anti-CPS responses in all three immunoglobulin classes, most notably IgA. The pneumococcal capsular polysaccharides used as antigens in the enzyme-linked immunosorbent assay were found to contain CPS in amounts ranging from less than 1 to 30%. As a result the enzyme-linked immunosorbent assay detected both anti-type-specific and anti-CPS antibodies. After elimination of the anti-CPS, type-specific pneumococcal antibodies were found only occasionally and in low concentrations in serum samples obtained in the acute phase of otitis or before vaccination. The infection induced homologous type-specific pneumococcal antibodies to varying degrees depending on the type: regularly to type 3; and fairly regularly to type 18C polysaccharide, but seldom to type 6 or 19. The pneumococcal vaccine induced type-specific antibodies to all four types measured, but the response to type 6A was poor.
Authors:
M Koskela
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  6     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-09-03     Completed Date:  1987-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antibodies, Bacterial / biosynthesis*
Bacterial Vaccines / immunology*
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin A / biosynthesis
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Immunoglobulins / biosynthesis
Infant
Otitis Media / immunology*
Pneumococcal Infections / immunology*
Pneumococcal Vaccines
Polysaccharides, Bacterial / immunology*
Streptococcus pneumoniae / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins; 0/Pneumococcal Vaccines; 0/Polysaccharides, Bacterial; 0/polysaccharide C-substance (Streptococcus)

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