Document Detail


Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles.
MedLine Citation:
PMID:  21882017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate predictive role of day-3 serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles.
MATERIALS AND METHODS: Forty-one women with moderate/severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E(2), FSH, LH, AMH, inhibin-B levels measured on day 3 of the menstrual cycle before controlled ovarian hyperstimulation.
RESULTS: Mean FSH was significantly lower (p < 0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p = 0.049, p < 0.0001 and p < 0.0001, respectively). There was no significant difference in inhibin B (p = 0.112) and estradiol (p = 0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC = 0.87) and AFC (AUC = 0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC = 0.58) and LH (AUC = 0.61) had low accuracy. The cut-off value for AMH 3.3 ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV.
CONCLUSION: Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS.
Authors:
Pelin Ocal; Sezai Sahmay; Meral Cetin; Tulay Irez; Onur Guralp; Ismail Cepni
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Publication Detail:
Type:  Journal Article     Date:  2011-09-01
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  28     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-11-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1197-203     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Fatih, Istanbul, Turkey. drpelinocal@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Mullerian Hormone / blood*
Biological Markers / blood
Cell Count
Female
Fertilization in Vitro
Follicle Stimulating Hormone / blood
Humans
Inhibins / blood
Middle Aged
Ovarian Follicle / pathology,  physiology*
Ovarian Hyperstimulation Syndrome / metabolism*,  pathology
Reproductive Techniques, Assisted
Chemical
Reg. No./Substance:
0/Biological Markers; 0/inhibin B; 57285-09-3/Inhibins; 80497-65-0/Anti-Mullerian Hormone; 9002-68-0/Follicle Stimulating Hormone
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