| Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles. | |
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MedLine Citation:
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PMID: 21882017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate predictive role of day-3 serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles. MATERIALS AND METHODS: Forty-one women with moderate/severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E(2), FSH, LH, AMH, inhibin-B levels measured on day 3 of the menstrual cycle before controlled ovarian hyperstimulation. RESULTS: Mean FSH was significantly lower (p < 0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p = 0.049, p < 0.0001 and p < 0.0001, respectively). There was no significant difference in inhibin B (p = 0.112) and estradiol (p = 0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC = 0.87) and AFC (AUC = 0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC = 0.58) and LH (AUC = 0.61) had low accuracy. The cut-off value for AMH 3.3 ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV. CONCLUSION: Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS. |
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Authors:
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Pelin Ocal; Sezai Sahmay; Meral Cetin; Tulay Irez; Onur Guralp; Ismail Cepni |
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Publication Detail:
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Type: Journal Article Date: 2011-09-01 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 28 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: 2012-11-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1197-203 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Fatih, Istanbul, Turkey. drpelinocal@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Mullerian Hormone / blood* Biological Markers / blood Cell Count Female Fertilization in Vitro Follicle Stimulating Hormone / blood Humans Inhibins / blood Middle Aged Ovarian Follicle / pathology, physiology* Ovarian Hyperstimulation Syndrome / metabolism*, pathology Reproductive Techniques, Assisted |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/inhibin B; 57285-09-3/Inhibins; 80497-65-0/Anti-Mullerian Hormone; 9002-68-0/Follicle Stimulating Hormone |
| Comments/Corrections | |
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