| Serum anti-S100b, anti-GFAP and anti-NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders. | |
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MedLine Citation:
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PMID: 10958173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural autoantibodies of IgG class to proteins S100b, glial fibrillar acidic protein (GFAP), and nerve growth factor (NGF) are presented in serum of healthy adults and those levels/affinities are relatively constant and may vary among individuals within narrow limits. In patients with depressive disorder, epilepsy, multiple sclerosis, and Parkinson's disease dispersion of such autoantibodies serum levels were often found beyond the normal ranges. Most of the patient groups include cases with significantly elevated as well as abnormally decreased immunoreactivity parameters. This leads us to assumption that changes in some basic mechanisms of individual immune state represent the common features of different forms of pathology of the nervous system. |
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Authors:
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A B Poletaev; S G Morozov; B B Gnedenko; V M Zlunikin; D A Korzhenevskey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Autoimmunity Volume: 32 ISSN: 0891-6934 ISO Abbreviation: Autoimmunity Publication Date: 2000 |
Date Detail:
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Created Date: 2000-11-21 Completed Date: 2000-12-22 Revised Date: 2005-11-04 |
Medline Journal Info:
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Nlm Unique ID: 8900070 Medline TA: Autoimmunity Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 33-8 Citation Subset: IM |
Affiliation:
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Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow. vtchernn@cityline.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibody Affinity Autoantibodies / blood* Calcium-Binding Proteins / immunology* Female Glial Fibrillary Acidic Protein / immunology* Humans Immunoblotting Immunoglobulin G / analysis* Male Mental Disorders / immunology* Middle Aged Nerve Growth Factor / immunology* Nerve Growth Factors / immunology* Nerve Tissue Proteins / immunology Nervous System Diseases / immunology* S100 Proteins* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Calcium-Binding Proteins; 0/Glial Fibrillary Acidic Protein; 0/Immunoglobulin G; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins; 9061-61-4/Nerve Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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