Document Detail


Serum anti-S100b, anti-GFAP and anti-NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders.
MedLine Citation:
PMID:  10958173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural autoantibodies of IgG class to proteins S100b, glial fibrillar acidic protein (GFAP), and nerve growth factor (NGF) are presented in serum of healthy adults and those levels/affinities are relatively constant and may vary among individuals within narrow limits. In patients with depressive disorder, epilepsy, multiple sclerosis, and Parkinson's disease dispersion of such autoantibodies serum levels were often found beyond the normal ranges. Most of the patient groups include cases with significantly elevated as well as abnormally decreased immunoreactivity parameters. This leads us to assumption that changes in some basic mechanisms of individual immune state represent the common features of different forms of pathology of the nervous system.
Authors:
A B Poletaev; S G Morozov; B B Gnedenko; V M Zlunikin; D A Korzhenevskey
Related Documents :
1203093 - A study of complement functions in a family with hereditary angioneurotic edema.
7368923 - Autoantibodies to tamm-horsfall protein in patients with cystic fibrosis.
264253 - A cephalometric guide to the diagnosis of midface hypoplasia at the le fort ii level.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autoimmunity     Volume:  32     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-21     Completed Date:  2000-12-22     Revised Date:  2005-11-04    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Affiliation:
Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow. vtchernn@cityline.ru
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibody Affinity
Autoantibodies / blood*
Calcium-Binding Proteins / immunology*
Female
Glial Fibrillary Acidic Protein / immunology*
Humans
Immunoblotting
Immunoglobulin G / analysis*
Male
Mental Disorders / immunology*
Middle Aged
Nerve Growth Factor / immunology*
Nerve Growth Factors / immunology*
Nerve Tissue Proteins / immunology
Nervous System Diseases / immunology*
S100 Proteins*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Calcium-Binding Proteins; 0/Glial Fibrillary Acidic Protein; 0/Immunoglobulin G; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins; 9061-61-4/Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relapsing arthritis induced by cell transfer from collagen-immunised mice.
Next Document:  Effect of anti-beta2glycoprotein I Lupus Anticoagulants on fibrin polymerization and fibrinolysis.