Document Detail

Serum androgens and depression in women with facial hirsutism.
MedLine Citation:
PMID:  1430353     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies on the psychopathologic aspects of hirsutism are sparse. Attempts to correlate these aspects with either the extent of the facial hirsutism and/or circulating serum androgens are virtually nonexistent. This study evaluates the psychopathologic aspects of hirsutism and correlates these findings with the extent of the facial hirsutism as well as with the circulating serum androgens. OBJECTIVE: Our purpose was to assess the psychopathologic aspects of facial hirsutism and to determine whether any correlation exists between these findings and either the extent of the facial hirsutism or the circulating serum androgens. METHODS: Twenty consecutive women with facial hirsutism were studied by administration of psychologic tests (DeRogatis Symptom Inventory and the Affects Balance Scale). The results of these tests were correlated with the grade of facial hirsutism as well as serum levels of total testosterone (T), biologically active testosterone (BT), free testosterone (FT), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A-dione). RESULTS: Significant levels of depression were found. No correlation was found between the psychopathologic measurements and the extent of facial hirsutism or serum levels of T, DHEA, DHEA-S, and A-dione. Significant correlations were found between depression and serum levels of FT and BT. CONCLUSION: There is an increased incidence of depression in facially hirsute women and this correlates with their circulating active testosterone levels and not with the extent of their facial hirsutism.
L H Shulman; L DeRogatis; R Spielvogel; J L Miller; L I Rose
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  27     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Department of Medicine, Hahnemann University School of Medicine, Philadelphia, PA.
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MeSH Terms
Androgens / blood*
Androstenedione / blood
Dehydroepiandrosterone / blood
Depression / etiology*
Hirsutism / blood*,  psychology*
Prospective Studies
Psychological Tests
Testosterone / blood
Reg. No./Substance:
0/Androgens; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 63-05-8/Androstenedione
Comment In:
J Am Acad Dermatol. 1993 Aug;29(2 Pt 1):286   [PMID:  8335761 ]

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